STRINGSTRING
SRC SRC CTBP1 CTBP1 FOS FOS IL6-2 IL6-2 EGR1 EGR1 CD2AP CD2AP SMAD3 SMAD3 TGFB1 TGFB1 GRB2 GRB2 MPO MPO TGFB3 TGFB3 FLT3 FLT3 CBL CBL TGFB2 TGFB2 CD34 CD34 MTOR MTOR MCL1 MCL1 ABCB1 ABCB1 NAB1 NAB1 CSF3 CSF3 ABI1 ABI1 IL6 IL6 EGFR EGFR ABI2 ABI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRCTyrosine-protein kinase. (542 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL6-2Interleukin 6. (234 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
CD2APCD2-associated protein. (650 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MPOMyeloperoxidase. (745 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CD34CD34 isoform 1. (328 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
MCL1Myeloid cell leukemia sequence 1 (BCL2-related). (350 aa)
ABCB1ATP binding cassette subfamily B member 1. (1280 aa)
NAB1NGFI-A binding protein 1 (EGR1 binding protein 1). (487 aa)
CSF3Colony stimulating factor 3 (Granulocyte). (204 aa)
ABI1Abl interactor 1. (508 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ABI2Abl interactor 2. (513 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.