STRINGSTRING
FGF20 FGF20 PRDM14 PRDM14 FGFR3 FGFR3 FGF11 FGF11 FGF12 FGF12 PXDN PXDN FGF4 FGF4 COL4A1 COL4A1 FGF18 FGF18 FGF3 FGF3 APOA4 APOA4 NANOG NANOG ACVR1B ACVR1B FGF9 FGF9 FGF14 FGF14 BMP4 BMP4 OTX2 OTX2 TGFB3 TGFB3 FGF7 FGF7 FOXF1 FOXF1 WNT3 WNT3 COL1A1 COL1A1 GATA6 GATA6 TGFB1 TGFB1 FGF21 FGF21 LRP2 LRP2 COL6A3 COL6A3 BMP2 BMP2 TFAP2C TFAP2C CTSZ CTSZ PDGFRA PDGFRA KDR KDR AFP AFP FGF5 FGF5 FGF1 FGF1 FGFR4 FGFR4 PRDM1 PRDM1 FGF19 FGF19 FGFR2 FGFR2 NODAL NODAL DKK1 DKK1 CUBN CUBN TGFB2 TGFB2 LAMC1 LAMC1 CTSS CTSS RSPO3 RSPO3 CTSB CTSB PXDNL PXDNL SOX17 SOX17 CER1 CER1 FGF17 FGF17 CTSE CTSE FGF16 FGF16 APOC3 APOC3 APOB APOB SFRP1 SFRP1 APOE APOE ALB ALB FOXA1 FOXA1 ABCA1 ABCA1 FGF22 FGF22 TGFBR3 TGFBR3 PRKCI PRKCI FGF13 FGF13 SFRP5 SFRP5 LAMB1 LAMB1 MIXL1 MIXL1 ENSPTRP00000072249 ENSPTRP00000072249 SOX7 SOX7 TGFBR1 TGFBR1 LDLR LDLR FGF8 FGF8 SHH SHH GATA4 GATA4 CTSD CTSD APOC3-2 APOC3-2 WNT3-2 WNT3-2 LEFTY1 LEFTY1 BMP4-2 BMP4-2 TTR TTR FGF10 FGF10 TBX3 TBX3 FGF6 FGF6 LAMA1 LAMA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PRDM14PR/SET domain 14. (571 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
PXDNPeroxidasin homolog. (1479 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
APOA4Apolipoprotein A4. (396 aa)
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FOXF1FOXF1 isoform 1. (433 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
GATA6GATA binding protein 6. (594 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
LRP2LRP2 isoform 1. (4655 aa)
COL6A3COL6A3 isoform 2. (3177 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
TFAP2CTranscription factor AP-2 gamma. (450 aa)
CTSZCTSZ isoform 1; Belongs to the peptidase C1 family. (303 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
AFPAlpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin; Belongs to the ALB/AFP/VDB family. (622 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
PRDM1PR/SET domain 1. (825 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
NODALNODAL isoform 2. (347 aa)
DKK1Dickkopf-like protein 1. (289 aa)
CUBNCUBN isoform 1. (3623 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LAMC1Laminin subunit gamma 1. (1609 aa)
CTSSCTSS isoform 1; Belongs to the peptidase C1 family. (331 aa)
RSPO3RSPO3 isoform 1. (292 aa)
CTSBCTSB isoform 10; Belongs to the peptidase C1 family. (339 aa)
PXDNLPXDNL isoform 2. (1463 aa)
SOX17SOX17 isoform 1. (416 aa)
CER1CER1 isoform 1. (267 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
CTSECTSE isoform 1; Belongs to the peptidase A1 family. (396 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
APOC3APOC3 isoform 2. (99 aa)
APOBAPOB isoform 1. (4562 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
ALBALB isoform 2. (609 aa)
FOXA1FOXA1 isoform 1. (471 aa)
ABCA1ATP-binding cassette, sub-family A (ABC1), member 1. (2264 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
SFRP5Secreted frizzled related protein 5. (317 aa)
LAMB1LAMB1 isoform 5. (1789 aa)
MIXL1Mix paired-like homeobox. (232 aa)
ENSPTRP00000072249annotation not available (396 aa)
SOX7SRY-box transcription factor 7. (388 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
LDLRLDLR isoform 7. (917 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
GATA4GATA binding protein 4. (443 aa)
CTSDT0155181 isoform 2; Belongs to the peptidase A1 family. (619 aa)
APOC3-2Apolipoprotein C3. (99 aa)
WNT3-2Wnt family member 3. (290 aa)
LEFTY1Left-right determination factor. (366 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family. (163 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TBX3T-box transcription factor 3. (743 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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