18 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LCN2	Lipocalin 2. (240 aa)
	AQP4	AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
	PRKACA	PRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	CP	CP isoform 1; Belongs to the multicopper oxidase family. (1069 aa)
	CXCL1	C-X-C motif chemokine. (107 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	LCN2-2	LCN2 isoform 5; Belongs to the calycin superfamily. Lipocalin family. (200 aa)
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
	HTT	HTT isoform 1. (3131 aa)
	CCL2	C-C motif chemokine. (109 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	CASP6	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (293 aa)
	STAT3	Signal transducer and activator of transcription. (790 aa)
	CCND2	CCND2 isoform 1; Belongs to the cyclin family. (289 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	CASP6	ENSPTRP00000054330	ENSPTRP00000080795	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.853
CASP3	CCL2	ENSPTRP00000054330	ENSPTRP00000068745	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	C-C motif chemokine.	0.487
CASP3	HTT	ENSPTRP00000054330	ENSPTRP00000065166	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	HTT isoform 1.	0.590
CASP3	PSEN1	ENSPTRP00000054330	ENSPTRP00000011045	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.517
CASP3	PSEN2	ENSPTRP00000054330	ENSPTRP00000051089	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.470
CASP3	STAT3	ENSPTRP00000054330	ENSPTRP00000091410	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Signal transducer and activator of transcription.	0.683
CASP6	CASP3	ENSPTRP00000080795	ENSPTRP00000054330	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.853
CASP6	HTT	ENSPTRP00000080795	ENSPTRP00000065166	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	HTT isoform 1.	0.591
CCL2	CASP3	ENSPTRP00000068745	ENSPTRP00000054330	C-C motif chemokine.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.487
CCL2	CXCL1	ENSPTRP00000068745	ENSPTRP00000027773	C-C motif chemokine.	C-X-C motif chemokine.	0.926
CCL2	LCN2	ENSPTRP00000068745	ENSPTRP00000070420	C-C motif chemokine.	Lipocalin 2.	0.531
CCL2	LCN2-2	ENSPTRP00000068745	ENSPTRP00000048884	C-C motif chemokine.	LCN2 isoform 5; Belongs to the calycin superfamily. Lipocalin family.	0.531
CCL2	STAT3	ENSPTRP00000068745	ENSPTRP00000091410	C-C motif chemokine.	Signal transducer and activator of transcription.	0.696
CCND2	STAT3	ENSPTRP00000007779	ENSPTRP00000091410	CCND2 isoform 1; Belongs to the cyclin family.	Signal transducer and activator of transcription.	0.445
CP	CXCL1	ENSPTRP00000026710	ENSPTRP00000027773	CP isoform 1; Belongs to the multicopper oxidase family.	C-X-C motif chemokine.	0.409
CXCL1	CCL2	ENSPTRP00000027773	ENSPTRP00000068745	C-X-C motif chemokine.	C-C motif chemokine.	0.926
CXCL1	CP	ENSPTRP00000027773	ENSPTRP00000026710	C-X-C motif chemokine.	CP isoform 1; Belongs to the multicopper oxidase family.	0.409
CXCL1	LCN2	ENSPTRP00000027773	ENSPTRP00000070420	C-X-C motif chemokine.	Lipocalin 2.	0.446
CXCL1	LCN2-2	ENSPTRP00000027773	ENSPTRP00000048884	C-X-C motif chemokine.	LCN2 isoform 5; Belongs to the calycin superfamily. Lipocalin family.	0.446
CXCL1	STAT3	ENSPTRP00000027773	ENSPTRP00000091410	C-X-C motif chemokine.	Signal transducer and activator of transcription.	0.622