STRINGSTRING
CD52 CD52 MUC1 MUC1 SELL SELL SERPINC1 SERPINC1 CD34 CD34 PSEN1 PSEN1 GRB2 GRB2 CD22 CD22 TYROBP TYROBP SIGLEC11 SIGLEC11 SIGLEC1 SIGLEC1 ST6GAL1 ST6GAL1 EMCN EMCN EGF EGF TLR3 TLR3 TREM2 TREM2 C1GALT1 C1GALT1 VSIR VSIR SIGLEC6 SIGLEC6 CD22-2 CD22-2 SIGLEC15 SIGLEC15 SIGLEC8 SIGLEC8 SIGLEC13 SIGLEC13 SELE SELE GNE GNE PODXL PODXL SIGLEC7 SIGLEC7 SYK SYK CD33 CD33 SRC SRC FYN FYN CTLA4 CTLA4 LOC107968591 LOC107968591 CD47 CD47 CD24 CD24 LOC107966154 LOC107966154 SOCS3 SOCS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD52CD52 isoform 1. (61 aa)
MUC1Mucin 1, cell surface associated. (484 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia; Belongs to the selectin/LECAM family. (385 aa)
SERPINC1Serpin family C member 1; Belongs to the serpin family. (464 aa)
CD34CD34 isoform 1. (328 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
CD22B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...] (847 aa)
TYROBPTYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (144 aa)
SIGLEC11T0182583 isoform 1. (703 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1709 aa)
ST6GAL1ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (406 aa)
EMCNEMCN isoform 1. (260 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (371 aa)
VSIRChromosome 10 open reading frame 54. (311 aa)
SIGLEC6Sialic acid binding Ig like lectin 6. (453 aa)
CD22-2B-cell receptor CD22. (626 aa)
SIGLEC15Sialic acid binding Ig like lectin 15. (328 aa)
SIGLEC8Sialic acid-binding Ig-like lectin 12; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. (597 aa)
SIGLEC13Sialic acid-binding Ig-like lectin 13; Putative adhesion molecule that mediates sialic-acid dependent binding to cells; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. (387 aa)
SELESELE isoform 1. (612 aa)
GNEGlucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase. (753 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (556 aa)
SIGLEC7Sialic acid binding Ig like lectin 7. (468 aa)
SYKTyrosine-protein kinase. (635 aa)
CD33CD33 isoform 4. (364 aa)
SRCTyrosine-protein kinase. (542 aa)
FYNTyrosine-protein kinase. (537 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
LOC107968591CD24 isoform 1. (80 aa)
CD47CD47 isoform 2. (323 aa)
CD24CD24 isoform 8. (129 aa)
LOC107966154SIGLEC8 isoform 2. (499 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.