37 items (Pan troglodytes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Predicted Interactions

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Your Input:
	SIGLEC1	Sialic acid binding Ig like lectin 1. (1709 aa)
	SIGLEC11	T0182583 isoform 1. (703 aa)
	TYROBP	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (144 aa)
	CD22	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...] (847 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	CD34	CD34 isoform 1. (328 aa)
	SERPINC1	Serpin family C member 1; Belongs to the serpin family. (464 aa)
	SELL	L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia; Belongs to the selectin/LECAM family. (385 aa)
	MUC1	Mucin 1, cell surface associated. (484 aa)
	CD52	CD52 isoform 1. (61 aa)
	SOCS3	Suppressor of cytokine signaling 3. (225 aa)
	LOC107966154	SIGLEC8 isoform 2. (499 aa)
	CD24	CD24 isoform 8. (129 aa)
	CD47	CD47 isoform 2. (323 aa)
	LOC107968591	CD24 isoform 1. (80 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	CD33	CD33 isoform 4. (364 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	SIGLEC7	Sialic acid binding Ig like lectin 7. (468 aa)
	PODXL	Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (556 aa)
	GNE	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase. (753 aa)
	SELE	SELE isoform 1. (612 aa)
	SIGLEC13	Sialic acid-binding Ig-like lectin 13; Putative adhesion molecule that mediates sialic-acid dependent binding to cells; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. (387 aa)
	SIGLEC8	Sialic acid-binding Ig-like lectin 12; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. (597 aa)
	SIGLEC15	Sialic acid binding Ig like lectin 15. (328 aa)
	CD22-2	B-cell receptor CD22. (626 aa)
	SIGLEC6	Sialic acid binding Ig like lectin 6. (453 aa)
	VSIR	Chromosome 10 open reading frame 54. (311 aa)
	C1GALT1	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (371 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
	EMCN	EMCN isoform 1. (260 aa)
	ST6GAL1	ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (406 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1GALT1	MUC1	ENSPTRP00000032336	ENSPTRP00000002386	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.	Mucin 1, cell surface associated.	0.599
C1GALT1	ST6GAL1	ENSPTRP00000032336	ENSPTRP00000027049	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.	ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family.	0.468
CD22	CD24	ENSPTRP00000018557	ENSPTRP00000081725	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	CD24 isoform 8.	0.463
CD22	CD34	ENSPTRP00000018557	ENSPTRP00000003262	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	CD34 isoform 1.	0.508
CD22	CD52	ENSPTRP00000018557	ENSPTRP00000000668	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	CD52 isoform 1.	0.564
CD22	CTLA4	ENSPTRP00000018557	ENSPTRP00000080210	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	Cytotoxic T-lymphocyte associated protein 4.	0.635
CD22	GRB2	ENSPTRP00000018557	ENSPTRP00000016382	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	Growth factor receptor-bound protein 2.	0.683
CD22	PODXL	ENSPTRP00000018557	ENSPTRP00000073254	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family.	0.435
CD22	SIGLEC1	ENSPTRP00000018557	ENSPTRP00000022624	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	Sialic acid binding Ig like lectin 1.	0.626
CD22	SIGLEC11	ENSPTRP00000018557	ENSPTRP00000019457	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	T0182583 isoform 1.	0.497
CD22	SIGLEC15	ENSPTRP00000018557	ENSPTRP00000049394	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	Sialic acid binding Ig like lectin 15.	0.838
CD22	ST6GAL1	ENSPTRP00000018557	ENSPTRP00000027049	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family.	0.493
CD22	SYK	ENSPTRP00000018557	ENSPTRP00000074883	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	Tyrosine-protein kinase.	0.830
CD22	TREM2	ENSPTRP00000018557	ENSPTRP00000031017	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	Triggering receptor expressed on myeloid cells 2.	0.422
CD22	TYROBP	ENSPTRP00000018557	ENSPTRP00000018632	B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that b [...]	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]	0.558
CD22-2	FYN	ENSPTRP00000048802	ENSPTRP00000077482	B-cell receptor CD22.	Tyrosine-protein kinase.	0.540
CD22-2	MUC1	ENSPTRP00000048802	ENSPTRP00000002386	B-cell receptor CD22.	Mucin 1, cell surface associated.	0.726
CD22-2	PODXL	ENSPTRP00000048802	ENSPTRP00000073254	B-cell receptor CD22.	Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family.	0.506
CD22-2	SIGLEC1	ENSPTRP00000048802	ENSPTRP00000022624	B-cell receptor CD22.	Sialic acid binding Ig like lectin 1.	0.454
CD22-2	SIGLEC15	ENSPTRP00000048802	ENSPTRP00000049394	B-cell receptor CD22.	Sialic acid binding Ig like lectin 15.	0.896