STRINGSTRING
HES5 HES5 PGK1 PGK1 EGF EGF LOC112209457 LOC112209457 PDGFRA PDGFRA HIST1H3A HIST1H3A DLX2 DLX2 HOXB2 HOXB2 VTN VTN TP53 TP53 GAPDH GAPDH NES NES H3-4 H3-4 GAD2 GAD2 HEYL HEYL ATRX ATRX ENSPTRP00000087266 ENSPTRP00000087266 HES5-2 HES5-2 LOC107966300 LOC107966300 ASCL1 ASCL1 CDKN2A CDKN2A NOTCH2 NOTCH2 SHH SHH FGF8 FGF8 EGFR EGFR DLL3 DLL3 ZMYND11 ZMYND11 BDNF BDNF MYCN MYCN ACTB ACTB ALB ALB FOXG1 FOXG1 H3C13 H3C13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HES5Hes family bHLH transcription factor 5. (165 aa)
PGK1Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (459 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
LOC112209457HIST1H3A isoform 1. (136 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
HIST1H3AH3F3B isoform 13. (136 aa)
DLX2Distal-less homeobox 2. (328 aa)
HOXB2HOXB2 isoform 1. (356 aa)
VTNVTN isoform 1. (478 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1620 aa)
H3-4HIST3H3 isoform 1. (136 aa)
GAD2Glutamate decarboxylase 2. (585 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
ATRXTranscriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase a [...] (2492 aa)
ENSPTRP00000087266Phosphoglycerate kinase 1. (394 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
LOC107966300Histone H3. (136 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
ZMYND11Zinc finger, MYND-type containing 11. (648 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
MYCNMYCN isoform 2. (464 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
ALBALB isoform 2. (609 aa)
FOXG1FOXG1 isoform 8. (489 aa)
H3C13HIST2H3A isoform 1. (136 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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