65 items (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	HAPLN1	Hyaluronan and proteoglycan link protein 1. (354 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	WDR62	WDR62 isoform 2. (1523 aa)
	NOTCH3	NOTCH3 isoform 1. (2321 aa)
	ADAM10	ADAM metallopeptidase domain 10. (748 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	TRNP1	TMF1-regulated nuclear protein 1. (227 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	ROBO2	Roundabout guidance receptor 2. (1439 aa)
	LUM	LUM isoform 1. (338 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	EMX2	Empty spiracles homeobox 2. (252 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	FGFR3	Fibroblast growth factor receptor. (808 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SLIT1	Slit guidance ligand 1. (1534 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	SATB2	DNA-binding protein SATB. (733 aa)
	CDK5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
	FEZF2	FEZ family zinc finger 2. (463 aa)
	LEF1	Lymphoid enhancer binding factor 1. (414 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	AR	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	NPAS3	NPAS3 isoform 1. (937 aa)
	FOXP2	Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). (741 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
	DCX	DCX isoform 5. (420 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	FGFR1	Fibroblast growth factor receptor. (854 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	EMX1	Empty spiracles homeobox 1. (290 aa)
	RELN	RELN isoform 3. (3460 aa)
	SP8	Sp8 transcription factor. (507 aa)
	FOXG1	FOXG1 isoform 8. (489 aa)
	SRGAP2	SRGAP2 isoform 1. (1071 aa)
	ROBO4	ROBO4 isoform 3. (1007 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	SOX6	SOX6 isoform 9. (828 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	GLI2	GLI family zinc finger 2. (1587 aa)
	LHX2	LHX2 isoform 1. (406 aa)
	GADD45G	Growth arrest and DNA-damage-inducible, gamma. (159 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	DLL1	ENSPTRP00000012167	ENSPTRP00000032142	ADAM metallopeptidase domain 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.695
ADAM10	EGF	ENSPTRP00000012167	ENSPTRP00000028112	ADAM metallopeptidase domain 10.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.495
ADAM10	FGF10	ENSPTRP00000012167	ENSPTRP00000083399	ADAM metallopeptidase domain 10.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.403
ADAM10	JAG1	ENSPTRP00000012167	ENSPTRP00000022729	ADAM metallopeptidase domain 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.592
ADAM10	NOTCH3	ENSPTRP00000012167	ENSPTRP00000018116	ADAM metallopeptidase domain 10.	NOTCH3 isoform 1.	0.541
ADAM10	RBPJ	ENSPTRP00000012167	ENSPTRP00000079413	ADAM metallopeptidase domain 10.	Recombination signal binding protein for immunoglobulin kappa J region.	0.448
AR	EGF	ENSPTRP00000076864	ENSPTRP00000028112	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.627
AR	FOXG1	ENSPTRP00000076864	ENSPTRP00000052740	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	FOXG1 isoform 8.	0.419
AR	GADD45G	ENSPTRP00000076864	ENSPTRP00000036056	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Growth arrest and DNA-damage-inducible, gamma.	0.800
AR	GLI2	ENSPTRP00000076864	ENSPTRP00000040313	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	GLI family zinc finger 2.	0.457
BMP4	DLX2	ENSPTRP00000010780	ENSPTRP00000021601	Bone morphogenetic protein 4.	Distal-less homeobox 2.	0.482
BMP4	EGF	ENSPTRP00000010780	ENSPTRP00000028112	Bone morphogenetic protein 4.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.495
BMP4	FGF10	ENSPTRP00000010780	ENSPTRP00000083399	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.696
BMP4	FGF13	ENSPTRP00000010780	ENSPTRP00000067255	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.553
BMP4	FGF16	ENSPTRP00000010780	ENSPTRP00000045123	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.471
BMP4	FGF17	ENSPTRP00000010780	ENSPTRP00000042446	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.471
BMP4	FGF18	ENSPTRP00000010780	ENSPTRP00000091453	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.594
BMP4	FGF20	ENSPTRP00000010780	ENSPTRP00000086042	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.405
BMP4	FGF22	ENSPTRP00000010780	ENSPTRP00000065736	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.472
BMP4	FGF3	ENSPTRP00000010780	ENSPTRP00000006880	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.495