STRINGSTRING
SOX2 SOX2 TBR1 TBR1 SMO SMO NES NES SATB2 SATB2 PRNP PRNP NDE1 NDE1 PAX6 PAX6 SOX1 SOX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX2SRY-box transcription factor 2. (319 aa)
TBR1T-box brain transcription factor 1. (682 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1620 aa)
SATB2DNA-binding protein SATB. (733 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (253 aa)
NDE1NudE nuclear distribution gene E homolog 1. (359 aa)
PAX6PAX6 isoform 13. (436 aa)
SOX1SOX1 isoform 1. (391 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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