STRINGSTRING
TNKS TNKS CXCR4 CXCR4 FGF2 FGF2 SST SST AFP AFP HOXA5 HOXA5 DNMT3L DNMT3L NOG NOG HOXB4 HOXB4 VTN VTN BMP4 BMP4 LCOR LCOR TNKS2 TNKS2 CD34 CD34 DNMT1 DNMT1 GATA2 GATA2 WNT3A WNT3A GCG GCG ACE ACE CDX4 CDX4 ACE2 ACE2 PXDNL PXDNL ENSPTRP00000080279 ENSPTRP00000080279 BMP4-2 BMP4-2 DNMT1-2 DNMT1-2 SHH SHH GATA1 GATA1 FOXA2 FOXA2 PXDN PXDN STAT3 STAT3 RUNX1 RUNX1 INS INS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (423 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
SSTSST isoform 1. (116 aa)
AFPAlpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin; Belongs to the ALB/AFP/VDB family. (622 aa)
HOXA5HOXA5 isoform 1. (270 aa)
DNMT3LT0078603 isoform 1. (387 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HOXB4HOXB4 isoform 1. (251 aa)
VTNVTN isoform 1. (478 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
LCORLigand dependent nuclear receptor corepressor. (1556 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
CD34CD34 isoform 1. (328 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1674 aa)
GATA2GATA binding protein 2. (480 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
GCGGCG isoform 1. (180 aa)
ACEAngiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. (1306 aa)
CDX4Caudal type homeobox 4. (284 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
PXDNLPXDNL isoform 2. (1463 aa)
ENSPTRP00000080279annotation not available (270 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
DNMT1-2DNA methyltransferase 1. (1674 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
GATA1GATA binding protein 1. (413 aa)
FOXA2FOXA2 isoform 1. (464 aa)
PXDNPeroxidasin homolog. (1479 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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