STRINGSTRING
CHD1 CHD1 TAF3 TAF3 MEN1 MEN1 NPAS4 NPAS4 PHF23 PHF23 NF1 NF1 KAT2A KAT2A KAT7 KAT7 BPTF BPTF JMJD6 JMJD6 CALM3 CALM3 DPY30 DPY30 NCOA6 NCOA6 EP300 EP300 KAT2B KAT2B SPRY4 SPRY4 ESR1 ESR1 CHD7 CHD7 ACE2 ACE2 SPIN1 SPIN1 KMT2C KMT2C PRDM9 PRDM9 KDM5A KDM5A RBBP5 RBBP5 WDR82 WDR82 SETD1B SETD1B KDM1A KDM1A FOXA1 FOXA1 GATA3 GATA3 CALM2 CALM2 HBA1 HBA1 PRMT1 PRMT1 ASH2L ASH2L WDR5 WDR5 IRF7 IRF7 CDK7 CDK7 KDM5B KDM5B HDAC1 HDAC1 KMT2A KMT2A CXXC1 CXXC1 CK820_G0042976 CK820_G0042976 CHIA CHIA CALM1 CALM1 FTH1 FTH1 HBA2 HBA2 BPTF-2 BPTF-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHD1Chromodomain helicase DNA binding protein 1. (1710 aa)
TAF3TATA-box binding protein associated factor 3. (931 aa)
MEN1MEN1 isoform 14. (615 aa)
NPAS4Neuronal PAS domain protein 4. (802 aa)
PHF23PHD finger protein 23. (403 aa)
NF1Neurofibromin 1. (2839 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
BPTFBPTF isoform 2. (3043 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (420 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
DPY30Dpy-30 histone methyltransferase complex regulatory subunit. (99 aa)
NCOA6Nuclear receptor coactivator 6. (2066 aa)
EP300E1A binding protein p300. (2175 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
SPRY4SPRY4 isoform 1. (322 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
CHD7CHD7 isoform 1. (2997 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
SPIN1SPIN1 isoform 1. (262 aa)
KMT2CKMT2C isoform 1. (4878 aa)
PRDM9PRDM9 isoform 1. (725 aa)
KDM5ALysine (K)-specific demethylase 5A. (1690 aa)
RBBP5RB binding protein 5, histone lysine methyltransferase complex subunit. (548 aa)
WDR82WD repeat domain 82. (313 aa)
SETD1BSETD1B isoform 3. (1962 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
FOXA1FOXA1 isoform 1. (471 aa)
GATA3GATA binding protein 3. (444 aa)
CALM2CALM2 isoform 7; Belongs to the calmodulin family. (196 aa)
HBA1Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
ASH2LASH2 like, histone lysine methyltransferase complex subunit. (639 aa)
WDR5WD repeat domain 5. (334 aa)
IRF7Interferon regulatory factor 7. (516 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
KDM5BKDM5B isoform 2. (1580 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3983 aa)
CXXC1CXXC finger protein 1. (667 aa)
CK820_G0042976KMT2C isoform 2. (4907 aa)
CHIACHIA isoform 3; Belongs to the glycosyl hydrolase 18 family. (466 aa)
CALM1CALM1 isoform 3; Belongs to the calmodulin family. (150 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
HBA2Pan troglodytes hemoglobin subunit alpha 2 (HBA2), mRNA. (145 aa)
BPTF-2BPTF isoform 1. (2776 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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