STRINGSTRING
USF1 USF1 BSND BSND ACKR1 ACKR1 HBB HBB AS3MT AS3MT IRAK4 IRAK4 SLC16A11 SLC16A11 AMH AMH TLR3 TLR3 CYP3A5 CYP3A5 GNB3 GNB3 LIPC LIPC CD4 CD4 CCDC57 CCDC57 ALB ALB SLC12A1 SLC12A1 MYD88 MYD88 AGTR1 AGTR1 AQP2 AQP2 CXCR4 CXCR4 SLC6A11 SLC6A11 INS INS SP3 SP3 ATP1A1 ATP1A1 MGP MGP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
USF1Upstream transcription factor 1. (310 aa)
BSNDBSND isoform 1. (320 aa)
ACKR1Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...] (336 aa)
HBBHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (147 aa)
AS3MTArsenite methyltransferase. (375 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
SLC16A11SLC16A11 isoform 1. (471 aa)
AMHAnti-Mullerian hormone. (560 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
CYP3A5CYP3A5 isoform 1. (493 aa)
GNB3G protein subunit beta 3. (340 aa)
LIPCLipase C, hepatic type. (499 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
CCDC57CCDC57 isoform 3. (915 aa)
ALBALB isoform 2. (609 aa)
SLC12A1Solute carrier family 12 member 1. (1099 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. (394 aa)
AQP2AQP2 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (423 aa)
SLC6A11Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (632 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
SP3Sp3 transcription factor. (781 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (128 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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