STRINGSTRING
CD63 CD63 CD3E CD3E IFNG IFNG ICOS ICOS ENSPTRP00000029460 ENSPTRP00000029460 TSPAN33 TSPAN33 IL13-2 IL13-2 LCN2-2 LCN2-2 CD4 CD4 SLPI SLPI ALB ALB TSPAN33-2 TSPAN33-2 IGF1 IGF1 CD40 CD40 LCN2 LCN2 CXCR5 CXCR5 CD40LG CD40LG IL5 IL5 SPIC SPIC TEAD2 TEAD2 IL13 IL13 CD44 CD44
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD63Tetraspanin. (238 aa)
CD3ECD3E isoform 2. (207 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
ICOSInducible T cell costimulator. (199 aa)
ENSPTRP00000029460Interleukin 5. (134 aa)
TSPAN33Tetraspanin. (283 aa)
IL13-2Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (146 aa)
LCN2-2LCN2 isoform 5; Belongs to the calycin superfamily. Lipocalin family. (200 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa)
SLPISecretory leukocyte peptidase inhibitor. (132 aa)
ALBALB isoform 2. (609 aa)
TSPAN33-2Tetraspanin 33. (283 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
CD40CD40 molecule, TNF receptor superfamily member 5. (277 aa)
LCN2Lipocalin 2. (240 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
SPICSpi-C transcription factor. (250 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
IL13Interleukin 13. (146 aa)
CD44CD44 isoform 3. (742 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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