STRINGSTRING
SOX8 SOX8 FGF3 FGF3 OPCML OPCML POU4F1 POU4F1 TUB TUB FGF19 FGF19 FGF4 FGF4 FGF9 FGF9 GSX1 GSX1 FGF14 FGF14 FGF7 FGF7 DNASE1L2 DNASE1L2 FGF21 FGF21 TMEM169 TMEM169 GSX2 GSX2 FGF5 FGF5 FGF1 FGF1 PXDNL PXDNL CK820_G0018745 CK820_G0018745 FGF17 FGF17 FGF16 FGF16 TBR1 TBR1 DNM3 DNM3 SP8 SP8 RNF38 RNF38 DNASE1L3 DNASE1L3 PAX6 PAX6 FGF22 FGF22 FGF13 FGF13 PDE4D PDE4D FGF2 FGF2 DNASE1L1 DNASE1L1 FGF8 FGF8 SHH SHH INS INS L1CAM L1CAM FGF10 FGF10 FGF6 FGF6 FGF20 FGF20 FGFR3 FGFR3 FGF11 FGF11 FGF12 FGF12 CUX1 CUX1 PXDN PXDN FGF18 FGF18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX8SOX8 isoform 1. (446 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
OPCMLOpioid-binding protein/cell adhesion molecule; Binds opioids in the presence of acidic lipids; probably involved in cell contact; Belongs to the immunoglobulin superfamily. IgLON family. (345 aa)
POU4F1POU domain protein. (350 aa)
TUBTubby-like protein; Belongs to the TUB family. (561 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GSX1GSX1 isoform 1. (264 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (299 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
TMEM169Transmembrane protein 169. (297 aa)
GSX2GSX2 isoform 2. (304 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PXDNLPXDNL isoform 2. (1463 aa)
CK820_G0018745FZD8 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (628 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TBR1T-box brain transcription factor 1. (682 aa)
DNM3DNM3 isoform 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
SP8Sp8 transcription factor. (507 aa)
RNF38Ring finger protein 38. (517 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (305 aa)
PAX6PAX6 isoform 13. (436 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
PDE4DPhosphodiesterase. (809 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
DNASE1L1Deoxyribonuclease; Belongs to the DNase I family. (302 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
L1CAML1 cell adhesion molecule. (1257 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
CUX1Homeobox protein cut-like. (1515 aa)
PXDNPeroxidasin homolog. (1479 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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