16 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LHX2	LHX2 isoform 1. (406 aa)
	DMRT3	Doublesex and mab-3 related transcription factor 3. (472 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1198 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	SLC32A1	Solute carrier family 32 member 1. (525 aa)
	NTN1	NTN1 isoform 1. (604 aa)
	SLC18A3	Solute carrier family 18 member A3. (532 aa)
	MBP	Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). (304 aa)
	PAX2	PAX2 isoform 1. (417 aa)
	EFNB3	EFNB3 isoform 1; Belongs to the ephrin family. (340 aa)
	EPHA4	EPH receptor A4. (986 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	RELN	RELN isoform 3. (3460 aa)
	ALB	ALB isoform 2. (609 aa)
	GLI2	GLI family zinc finger 2. (1587 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	MBP	ENSPTRP00000056218	ENSPTRP00000091696	ALB isoform 2.	Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).	0.469
DMRT3	PAX2	ENSPTRP00000035459	ENSPTRP00000091068	Doublesex and mab-3 related transcription factor 3.	PAX2 isoform 1.	0.412
EFNB3	EPHA4	ENSPTRP00000087831	ENSPTRP00000086131	EFNB3 isoform 1; Belongs to the ephrin family.	EPH receptor A4.	0.996
EFNB3	SLC18A3	ENSPTRP00000087831	ENSPTRP00000004288	EFNB3 isoform 1; Belongs to the ephrin family.	Solute carrier family 18 member A3.	0.503
EFNB3	SLC32A1	ENSPTRP00000087831	ENSPTRP00000023163	EFNB3 isoform 1; Belongs to the ephrin family.	Solute carrier family 32 member 1.	0.433
EPHA4	EFNB3	ENSPTRP00000086131	ENSPTRP00000087831	EPH receptor A4.	EFNB3 isoform 1; Belongs to the ephrin family.	0.996
GLI2	GLI3	ENSPTRP00000040313	ENSPTRP00000032656	GLI family zinc finger 2.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.987
GLI2	SHH	ENSPTRP00000040313	ENSPTRP00000075730	GLI family zinc finger 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.846
GLI2	SMO	ENSPTRP00000040313	ENSPTRP00000033707	GLI family zinc finger 2.	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.884
GLI3	GLI2	ENSPTRP00000032656	ENSPTRP00000040313	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	GLI family zinc finger 2.	0.987
GLI3	SHH	ENSPTRP00000032656	ENSPTRP00000075730	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.862
GLI3	SMO	ENSPTRP00000032656	ENSPTRP00000033707	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.842
LHX2	PAX2	ENSPTRP00000036487	ENSPTRP00000091068	LHX2 isoform 1.	PAX2 isoform 1.	0.421
LHX2	SHH	ENSPTRP00000036487	ENSPTRP00000075730	LHX2 isoform 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.457
MBP	ALB	ENSPTRP00000091696	ENSPTRP00000056218	Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).	ALB isoform 2.	0.469
NTN1	SLC18A3	ENSPTRP00000014909	ENSPTRP00000004288	NTN1 isoform 1.	Solute carrier family 18 member A3.	0.404
PAX2	DMRT3	ENSPTRP00000091068	ENSPTRP00000035459	PAX2 isoform 1.	Doublesex and mab-3 related transcription factor 3.	0.412
PAX2	LHX2	ENSPTRP00000091068	ENSPTRP00000036487	PAX2 isoform 1.	LHX2 isoform 1.	0.421
PAX2	SHH	ENSPTRP00000091068	ENSPTRP00000075730	PAX2 isoform 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.479
SHH	GLI2	ENSPTRP00000075730	ENSPTRP00000040313	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	GLI family zinc finger 2.	0.846