STRINGSTRING
LHX2 LHX2 DMRT3 DMRT3 HIPK2 HIPK2 SMO SMO GLI3 GLI3 SLC32A1 SLC32A1 NTN1 NTN1 SLC18A3 SLC18A3 MBP MBP PAX2 PAX2 EFNB3 EFNB3 EPHA4 EPHA4 SHH SHH RELN RELN ALB ALB GLI2 GLI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LHX2LHX2 isoform 1. (406 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
SLC32A1Solute carrier family 32 member 1. (525 aa)
NTN1NTN1 isoform 1. (604 aa)
SLC18A3Solute carrier family 18 member A3. (532 aa)
MBPMyelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). (304 aa)
PAX2PAX2 isoform 1. (417 aa)
EFNB3EFNB3 isoform 1; Belongs to the ephrin family. (340 aa)
EPHA4EPH receptor A4. (986 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
RELNRELN isoform 3. (3460 aa)
ALBALB isoform 2. (609 aa)
GLI2GLI family zinc finger 2. (1587 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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