54 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HIST1H3A	H3F3B isoform 13. (136 aa)
	H3-4	HIST3H3 isoform 1. (136 aa)
	ENSPTRP00000006737	Barrier to autointegration factor 1. (89 aa)
	PAK1	Non-specific serine/threonine protein kinase. (553 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (1150 aa)
	CCNT1	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of SIV infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing [...] (725 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	FURIN	Furin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)
	PSMD11	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11. (422 aa)
	HEXIM2	Hexamthylene bis-acetamide inducible 2. (286 aa)
	KPNB1	Karyopherin (Importin) beta 1. (876 aa)
	RNASEH1	T0034625 isoform 1. (286 aa)
	NABP1	Oligonucleotide/oligosaccharide-binding fold containing 2A. (204 aa)
	CCR5	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
	NR3C1	NR3C1 isoform 5. (778 aa)
	LOC112209457	HIST1H3A isoform 1. (136 aa)
	SLC22A3	Solute carrier family 22 member 3. (556 aa)
	MEPCE	Methylphosphate capping enzyme. (689 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (878 aa)
	CDK9	Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
	SUV39H1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (423 aa)
	CUL4B	CUL4B isoform 3; Belongs to the cullin family. (932 aa)
	DKC1	Dyskeratosis congenita 1, dyskerin. (514 aa)
	H3C13	HIST2H3A isoform 1. (136 aa)
	FUS	FUS isoform 7. (526 aa)
	RELA	V-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
	MAML1	MAML1 isoform 1. (1016 aa)
	HNRNPK	Heterogeneous nuclear ribonucleoprotein K. (464 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1674 aa)
	IL6	Interleukin 6 (Interferon, beta 2). (234 aa)
	HEXIM1	Hexamethylene bis-acetamide inducible 1. (359 aa)
	DKC1-2	Dyskerin pseudouridine synthase 1. (591 aa)
	CXCR4	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (423 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
	EZH2	Enhancer of zeste homolog 2. (754 aa)
	LOC107966300	Histone H3. (136 aa)
	LARP7	La ribonucleoprotein domain family member 7. (589 aa)
	BANF1	Barrier to autointegration factor 1. (89 aa)
	MAML3	MAML3 isoform 1. (1134 aa)
	IL6-2	Interleukin 6. (234 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (347 aa)
	EMD	EMD isoform 1. (254 aa)
	SOD2	Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (238 aa)
	PPP2R1A	Protein phosphatase 2, regulatory subunit A, alpha. (637 aa)
	DNMT1-2	DNA methyltransferase 1. (1674 aa)
	MEPCE-2	Methylphosphate capping enzyme. (689 aa)
	FAS	Fas (TNF receptor superfamily, member 6). (337 aa)
	BRD4	Bromodomain containing 4. (1362 aa)
	EZH2-2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	SUV39H1-2	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
	ZEB2	Zinc finger E-box binding homeobox 2. (1253 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	EZH2	ENSPTRP00000035263	ENSPTRP00000077344	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Enhancer of zeste homolog 2.	0.523
AGO2	EZH2-2	ENSPTRP00000035263	ENSPTRP00000090461	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.523
AGO2	FUS	ENSPTRP00000035263	ENSPTRP00000053592	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	FUS isoform 7.	0.470
AGO2	H3-4	ENSPTRP00000035263	ENSPTRP00000002098	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	HIST3H3 isoform 1.	0.402
BANF1	BRD4	ENSPTRP00000079424	ENSPTRP00000089214	Barrier to autointegration factor 1.	Bromodomain containing 4.	0.433
BANF1	DKC1	ENSPTRP00000079424	ENSPTRP00000038696	Barrier to autointegration factor 1.	Dyskeratosis congenita 1, dyskerin.	0.480
BANF1	DKC1-2	ENSPTRP00000079424	ENSPTRP00000070218	Barrier to autointegration factor 1.	Dyskerin pseudouridine synthase 1.	0.480
BANF1	EMD	ENSPTRP00000079424	ENSPTRP00000082199	Barrier to autointegration factor 1.	EMD isoform 1.	0.968
BANF1	H3-4	ENSPTRP00000079424	ENSPTRP00000002098	Barrier to autointegration factor 1.	HIST3H3 isoform 1.	0.681
BANF1	H3C13	ENSPTRP00000079424	ENSPTRP00000048353	Barrier to autointegration factor 1.	HIST2H3A isoform 1.	0.419
BANF1	HIST1H3A	ENSPTRP00000079424	ENSPTRP00000021631	Barrier to autointegration factor 1.	H3F3B isoform 13.	0.425
BANF1	LOC107966300	ENSPTRP00000079424	ENSPTRP00000078706	Barrier to autointegration factor 1.	Histone H3.	0.419
BANF1	PPP2R1A	ENSPTRP00000079424	ENSPTRP00000083529	Barrier to autointegration factor 1.	Protein phosphatase 2, regulatory subunit A, alpha.	0.421
BRD4	BANF1	ENSPTRP00000089214	ENSPTRP00000079424	Bromodomain containing 4.	Barrier to autointegration factor 1.	0.433
BRD4	CCNT1	ENSPTRP00000089214	ENSPTRP00000008350	Bromodomain containing 4.	Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of SIV infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing [...]	0.988
BRD4	CDK9	ENSPTRP00000089214	ENSPTRP00000036573	Bromodomain containing 4.	Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily.	0.989
BRD4	DNMT1	ENSPTRP00000089214	ENSPTRP00000066034	Bromodomain containing 4.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.522
BRD4	DNMT1-2	ENSPTRP00000089214	ENSPTRP00000085699	Bromodomain containing 4.	DNA methyltransferase 1.	0.522
BRD4	ENSPTRP00000006737	ENSPTRP00000089214	ENSPTRP00000006737	Bromodomain containing 4.	Barrier to autointegration factor 1.	0.433
BRD4	EZH2	ENSPTRP00000089214	ENSPTRP00000077344	Bromodomain containing 4.	Enhancer of zeste homolog 2.	0.547