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ADORA1 ADORA1 TGFB2 TGFB2 UCP3 UCP3 BMP4 BMP4 TGFB3 TGFB3 ADORA2B ADORA2B SMAD4 SMAD4 TGFB1 TGFB1 IL1B IL1B PCNA PCNA SERPINI1 SERPINI1 NR3C1 NR3C1 FKBP5 FKBP5 PXDNL PXDNL NOTCH1 NOTCH1 HES5 HES5 GPX7 GPX7 ACHE ACHE GPX3 GPX3 GPX4 GPX4 GPX6 GPX6 GPX1 GPX1 GPX2 GPX2 ALDH3A1 ALDH3A1 BDNF BDNF GFAP GFAP FOXN3 FOXN3 GPX8 GPX8 SHH SHH HMGCR HMGCR INS INS PTN PTN HES5-2 HES5-2 BMP4-2 BMP4-2 CASP9 CASP9 PXDN PXDN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
SERPINI1Serpin peptidase inhibitor, clade I (Neuroserpin), member 1; Belongs to the serpin family. (410 aa)
NR3C1NR3C1 isoform 5. (778 aa)
FKBP5Peptidylprolyl isomerase. (457 aa)
PXDNLPXDNL isoform 2. (1463 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (187 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (617 aa)
GPX3GPX3 isoform 3. (225 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (233 aa)
GPX6Glutathione peroxidase 6 precursor. (220 aa)
GPX1Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (200 aa)
GPX2GPX2 isoform 4. (150 aa)
ALDH3A1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (453 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (505 aa)
FOXN3FOXN3 isoform 2. (490 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
PTNPTN isoform 2. (172 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
CASP9CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
PXDNPeroxidasin homolog. (1479 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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