node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACHE | BDNF | ENSPTRP00000046302 | ENSPTRP00000060385 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | 0.502 |
ACHE | GPX2 | ENSPTRP00000046302 | ENSPTRP00000052602 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | GPX2 isoform 4. | 0.509 |
ACHE | GPX3 | ENSPTRP00000046302 | ENSPTRP00000047900 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | GPX3 isoform 3. | 0.508 |
ACHE | GPX6 | ENSPTRP00000046302 | ENSPTRP00000050465 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Glutathione peroxidase 6 precursor. | 0.512 |
ACHE | GPX7 | ENSPTRP00000046302 | ENSPTRP00000040995 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | 0.511 |
ACHE | GPX8 | ENSPTRP00000046302 | ENSPTRP00000072779 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Glutathione peroxidase; Belongs to the glutathione peroxidase family. | 0.512 |
ACHE | IL1B | ENSPTRP00000046302 | ENSPTRP00000021191 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.464 |
ACHE | PXDN | ENSPTRP00000046302 | ENSPTRP00000090912 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Peroxidasin homolog. | 0.539 |
ACHE | PXDNL | ENSPTRP00000046302 | ENSPTRP00000034664 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | PXDNL isoform 2. | 0.539 |
ADORA1 | ADORA2B | ENSPTRP00000003131 | ENSPTRP00000015003 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | 0.939 |
ADORA2B | ADORA1 | ENSPTRP00000015003 | ENSPTRP00000003131 | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | 0.939 |
BDNF | ACHE | ENSPTRP00000060385 | ENSPTRP00000046302 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.502 |
BDNF | FKBP5 | ENSPTRP00000060385 | ENSPTRP00000030899 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Peptidylprolyl isomerase. | 0.518 |
BDNF | GFAP | ENSPTRP00000060385 | ENSPTRP00000062393 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Glial fibrillary acidic protein; Belongs to the intermediate filament family. | 0.636 |
BDNF | IL1B | ENSPTRP00000060385 | ENSPTRP00000021191 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.583 |
BDNF | INS | ENSPTRP00000060385 | ENSPTRP00000077843 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.508 |
BDNF | NR3C1 | ENSPTRP00000060385 | ENSPTRP00000029679 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | NR3C1 isoform 5. | 0.652 |
BDNF | PXDN | ENSPTRP00000060385 | ENSPTRP00000090912 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Peroxidasin homolog. | 0.508 |
BDNF | PXDNL | ENSPTRP00000060385 | ENSPTRP00000034664 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | PXDNL isoform 2. | 0.508 |
BDNF | SHH | ENSPTRP00000060385 | ENSPTRP00000075730 | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.568 |