STRINGSTRING
FGF5 FGF5 EGF EGF METTL14 METTL14 KDM3B KDM3B FGF1 FGF1 WTAP WTAP DLL1 DLL1 HDAC9 HDAC9 CLU CLU FMR1 FMR1 HES5 HES5 FGF17 FGF17 FGF16 FGF16 NSUN2 NSUN2 SOX2 SOX2 HDAC2 HDAC2 HMGA2 HMGA2 YTHDC1 YTHDC1 ADGRG1 ADGRG1 ZC3H13 ZC3H13 RPS6 RPS6 KDM6B KDM6B INSR INSR FBL FBL FGF22 FGF22 FGF13 FGF13 LOC736189 LOC736189 BCL6 BCL6 OLIG2 OLIG2 HDAC4 HDAC4 CREBBP CREBBP FGF8 FGF8 SHH SHH NOTCH2 NOTCH2 EZH2 EZH2 PHF21B PHF21B ASCL1 ASCL1 PRDM16 PRDM16 FOS FOS SATB2 SATB2 HES5-2 HES5-2 POU2F2 POU2F2 TMEM14B TMEM14B ITGB8 ITGB8 FGF10 FGF10 VIRMA VIRMA NEUROG2 NEUROG2 EGR1 EGR1 ITGB8-2 ITGB8-2 FGF6 FGF6 FGF20 FGF20 EED EED LIN28A LIN28A HDAC7 HDAC7 NEUROD2 NEUROD2 FGF11 FGF11 NTF3 NTF3 CUX2 CUX2 FGF12 FGF12 EZH2-2 EZH2-2 TRNP1 TRNP1 CUX1 CUX1 FGF18 FGF18 YTHDF1 YTHDF1 SIRT1-2 SIRT1-2 MTOR MTOR DMRTA2 DMRTA2 NES NES SIRT1 SIRT1 FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 FGF9 FGF9 EDNRB EDNRB FGF14 FGF14 ARHGAP11A ARHGAP11A FGF7 FGF7 SIN3B SIN3B IQGAP1 IQGAP1 CNOT1 CNOT1 FXR2 FXR2 SUZ12 SUZ12 HDAC5 HDAC5 FGF21 FGF21 OTX1 OTX1 FXR1 FXR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
KDM3BLysine (K)-specific demethylase 3B. (1761 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
WTAPWilms tumor 1 associated protein. (396 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
FMR1Fragile X mental retardation 1. (632 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
NSUN2NOP2/Sun domain family, member 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (767 aa)
SOX2SRY-box transcription factor 2. (319 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
YTHDC1YTH domain containing 1. (735 aa)
ADGRG1Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] (693 aa)
ZC3H13ZC3H13 isoform 1. (1667 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
KDM6BLysine demethylase 6B. (1679 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
FBLFBL isoform 1. (336 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
LOC736189FBL isoform 7. (299 aa)
BCL6BCL6 transcription repressor. (706 aa)
OLIG2OLIG2 isoform 1. (323 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
CREBBPCREB binding protein. (2442 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
PHF21BPHD finger protein 21B. (489 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
PRDM16PRDM16 isoform 4. (1276 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SATB2DNA-binding protein SATB. (733 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
POU2F2POU domain protein. (622 aa)
TMEM14BT0060485 isoform 1. (151 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
VIRMAVIRMA isoform 1. (1830 aa)
NEUROG2NEUROG2 isoform 1. (272 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
ITGB8-2Integrin subunit beta 8. (780 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
EEDEmbryonic ectoderm development. (466 aa)
LIN28ALIN28A isoform 1. (209 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
CUX2Homeobox protein cut-like. (1489 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
TRNP1TMF1-regulated nuclear protein 1. (227 aa)
CUX1Homeobox protein cut-like. (1515 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (584 aa)
SIRT1-2Sirtuin 1. (751 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
DMRTA2DMRT like family A2. (539 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1620 aa)
SIRT1SIRT1 isoform 2. (751 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
ARHGAP11AARHGAP11B isoform 3. (1023 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SIN3BSIN3 transcription regulator family member B. (1159 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
CNOT1CCR4-NOT transcription complex, subunit 1. (2383 aa)
FXR2Fragile X mental retardation, autosomal homolog 2. (673 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
OTX1Orthodenticle homeobox 1. (354 aa)
FXR1Fragile X mental retardation, autosomal homolog 1. (782 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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