STRINGSTRING
CDH7 CDH7 VIM VIM LHX5 LHX5 LGALS3 LGALS3 MEIS2 MEIS2 CRABP1 CRABP1 ORC4 ORC4 DLX2 DLX2 BMP7 BMP7 LIF LIF TOM1 TOM1 EOMES EOMES AGO2 AGO2 TTF1 TTF1 LYN LYN HS6ST2 HS6ST2 PTPRZ1 PTPRZ1 ITGB5 ITGB5 ASPM ASPM BCL11B BCL11B PAX6 PAX6 HOPX HOPX PALMD PALMD ID4 ID4 FAM107A FAM107A MAF MAF SHH SHH CDC42 CDC42 LIFR LIFR FEZF2 FEZF2 SATB2 SATB2 DLK1 DLK1 ATP1A2 ATP1A2 NHLH1 NHLH1 TKTL1 TKTL1 NTRK3 NTRK3 CUX2 CUX2 MEF2C MEF2C TAC3 TAC3 STAT3 STAT3 FBN2 FBN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDH7CDH7 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (466 aa)
LHX5LHX5 isoform 2. (402 aa)
LGALS3Galectin. (250 aa)
MEIS2MEIS2 isoform 1. (477 aa)
CRABP1Cellular retinoic acid binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
DLX2Distal-less homeobox 2. (328 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
TOM1TOM1 isoform 7; Belongs to the TOM1 family. (493 aa)
EOMESEOMES isoform 2. (704 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (878 aa)
TTF1Transcription termination factor 1. (905 aa)
LYNTyrosine-protein kinase. (512 aa)
HS6ST2Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (645 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2315 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
PAX6PAX6 isoform 13. (436 aa)
HOPXHOPX isoform 3. (112 aa)
PALMDPALMD isoform 1. (552 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
FAM107AActin-associated protein FAM107A; Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal [...] (175 aa)
MAFMAF isoform 2; Belongs to the bZIP family. (402 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
LIFRLeukemia inhibitory factor receptor alpha. (1097 aa)
FEZF2FEZ family zinc finger 2. (463 aa)
SATB2DNA-binding protein SATB. (733 aa)
DLK1Delta like non-canonical Notch ligand 1. (383 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
NHLH1Nescient helix-loop-helix 1. (133 aa)
TKTL1TKTL1 isoform 3. (598 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. (864 aa)
CUX2Homeobox protein cut-like. (1489 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
TAC3TAC3 isoform 1. (121 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
FBN2FBN2 isoform 1. (2912 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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