node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACE2 | CD4 | ENSPTRP00000037158 | ENSPTRP00000054833 | Angiotensin-converting enzyme. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.802 |
ACE2 | ERVFRD-1 | ENSPTRP00000037158 | ENSPTRP00000058789 | Angiotensin-converting enzyme. | Transmembrane protein; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (By similarity). | 0.576 |
ACE2 | IFNB1 | ENSPTRP00000037158 | ENSPTRP00000035597 | Angiotensin-converting enzyme. | Interferon beta 1. | 0.573 |
ACE2 | IL2 | ENSPTRP00000037158 | ENSPTRP00000028193 | Angiotensin-converting enzyme. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.922 |
ACE2 | IL6 | ENSPTRP00000037158 | ENSPTRP00000068252 | Angiotensin-converting enzyme. | Interleukin 6 (Interferon, beta 2). | 0.783 |
ACE2 | IL6-2 | ENSPTRP00000037158 | ENSPTRP00000080270 | Angiotensin-converting enzyme. | Interleukin 6. | 0.783 |
ACE2 | IL7 | ENSPTRP00000037158 | ENSPTRP00000079272 | Angiotensin-converting enzyme. | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. | 0.551 |
ACE2 | IRF3 | ENSPTRP00000037158 | ENSPTRP00000065398 | Angiotensin-converting enzyme. | Interferon regulatory factor 3. | 0.464 |
ACE2 | TLR3 | ENSPTRP00000037158 | ENSPTRP00000028569 | Angiotensin-converting enzyme. | Toll-like receptor 3; Belongs to the Toll-like receptor family. | 0.490 |
ACE2 | TLR7 | ENSPTRP00000037158 | ENSPTRP00000047494 | Angiotensin-converting enzyme. | Toll like receptor 7; Belongs to the Toll-like receptor family. | 0.522 |
ACE2 | TMPRSS2 | ENSPTRP00000037158 | ENSPTRP00000023965 | Angiotensin-converting enzyme. | Transmembrane serine protease 2; Belongs to the peptidase S1 family. | 0.969 |
ACE2 | TNF | ENSPTRP00000037158 | ENSPTRP00000069905 | Angiotensin-converting enzyme. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.699 |
CD4 | ACE2 | ENSPTRP00000054833 | ENSPTRP00000037158 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Angiotensin-converting enzyme. | 0.802 |
CD4 | CGAS | ENSPTRP00000054833 | ENSPTRP00000054197 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | MB21D1 isoform 1. | 0.664 |
CD4 | ERVFRD-1 | ENSPTRP00000054833 | ENSPTRP00000058789 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Transmembrane protein; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (By similarity). | 0.581 |
CD4 | IFNB1 | ENSPTRP00000054833 | ENSPTRP00000035597 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interferon beta 1. | 0.577 |
CD4 | IL2 | ENSPTRP00000054833 | ENSPTRP00000028193 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.933 |
CD4 | IL6 | ENSPTRP00000054833 | ENSPTRP00000068252 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interleukin 6 (Interferon, beta 2). | 0.897 |
CD4 | IL6-2 | ENSPTRP00000054833 | ENSPTRP00000080270 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interleukin 6. | 0.897 |
CD4 | IL7 | ENSPTRP00000054833 | ENSPTRP00000079272 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. | 0.837 |