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FABP4 | Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) | ||||
AHR | T0073207 isoform 1. (850 aa) | ||||
ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa) | ||||
BACH2 | BACH2 isoform 1. (973 aa) | ||||
ME1 | Malic enzyme. (572 aa) | ||||
GCLC | Glutamate-cysteine ligase, catalytic subunit. (637 aa) | ||||
CCNB1 | CCNB1 isoform 1; Belongs to the cyclin family. (433 aa) | ||||
PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa) | ||||
ADIPOQ | Adiponectin, C1Q and collagen domain containing. (244 aa) | ||||
ATF4 | Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa) | ||||
HMOX1 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa) | ||||
LIF | Leukemia inhibitory factor (Cholinergic differentiation factor). (202 aa) | ||||
JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) | ||||
MTHFD2 | MTHFD2 isoform 1. (350 aa) | ||||
FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) | ||||
KEAP1 | Kelch-like ECH-associated protein 1. (624 aa) | ||||
AXIN2 | AXIN2 isoform 1. (843 aa) | ||||
NQO1 | NAD(P)H quinone dehydrogenase 1. (274 aa) | ||||
CYP19A1 | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa) | ||||
NRL | Neural retina leucine zipper. (237 aa) | ||||
NANOG | Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa) | ||||
BACE1 | Beta-site APP-cleaving enzyme 1; Belongs to the peptidase A1 family. (501 aa) | ||||
CNTF | Ciliary neurotrophic factor. (200 aa) | ||||
MYOD1 | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa) | ||||
TALDO1 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa) | ||||
SIRT1 | SIRT1 isoform 2. (751 aa) | ||||
PHGDH | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (573 aa) | ||||
GCLM | Glutamate-cysteine ligase, modifier subunit. (274 aa) | ||||
PCSK9 | Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (813 aa) | ||||
APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa) | ||||
TKT | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (631 aa) | ||||
FTH1 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa) | ||||
ATG7 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa) | ||||
FXN | FXN isoform 1. (210 aa) | ||||
KRAS | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa) | ||||
CEBPB | CCAAT/enhancer-binding protein. (347 aa) | ||||
CCND1 | CCND1 isoform 1; Belongs to the cyclin family. (295 aa) | ||||
BCL2 | BCL2 apoptosis regulator. (239 aa) | ||||
PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) | ||||
STAT3 | Signal transducer and activator of transcription. (790 aa) | ||||
SIRT1-2 | Sirtuin 1. (751 aa) | ||||
LIFR | Leukemia inhibitory factor receptor alpha. (1097 aa) | ||||
FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) | ||||
PPARG | Peroxisome proliferator-activated receptor gamma isoform X2. (505 aa) | ||||
HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa) | ||||
EGFR | Receptor protein-tyrosine kinase. (1210 aa) | ||||
CDK12 | Cyclin-dependent kinase 12. (1490 aa) | ||||
IGF1 | Insulin-like growth factor 1 (Somatomedin C). (196 aa) | ||||
PTGR1 | Prostaglandin reductase 1. (329 aa) | ||||
RUNX2 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa) | ||||
HES1 | Hes family bHLH transcription factor 1. (280 aa) | ||||
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa) | ||||
SHMT2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa) | ||||
MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (499 aa) | ||||
FTL | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (182 aa) | ||||
PGD | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa) | ||||
CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) | ||||
GPX4 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (233 aa) | ||||
SQSTM1 | SQSTM1 isoform 4. (440 aa) | ||||
ARNT | Aryl hydrocarbon receptor nuclear translocator. (789 aa) | ||||
MYOG | MYOG isoform 1. (249 aa) | ||||
G6PD | Glucose-6-phosphate dehydrogenase. (560 aa) | ||||
FOXP3 | FOXP3 isoform 4. (456 aa) | ||||
TXN | Thioredoxin; Belongs to the thioredoxin family. (105 aa) | ||||
PSAT1 | Phosphoserine aminotransferase. (370 aa) |