STRINGSTRING
CRP CRP IL10 IL10 TGFB2 TGFB2 AGT AGT NRP1 NRP1 F2 F2 VWF VWF STAT6 STAT6 FLT1 FLT1 TGFB3 TGFB3 FURIN FURIN GOT2 GOT2 STAT5A STAT5A TGFB1 TGFB1 THBD THBD TMPRSS11A TMPRSS11A CXCL8 CXCL8 CSF2 CSF2 IL9 IL9 PLAT PLAT ACE2 ACE2 ACE ACE F3 F3 CSF3 CSF3 ALB ALB PGF PGF AGTR1 AGTR1 HP HP IL6 IL6 TNF TNF STAT4 STAT4 IL6-2 IL6-2 MFGE8 MFGE8 STAT5B STAT5B STAT1 STAT1 STAT3 STAT3 STAT2 STAT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRPPentaxin. (224 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
VWFVon Willebrand factor. (2813 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FURINFurin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)
GOT2Aspartate aminotransferase. (430 aa)
STAT5ASignal transducer and activator of transcription. (783 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
THBDTHBD isoform 1. (631 aa)
TMPRSS11ATransmembrane protease serine; Belongs to the peptidase S1 family. (421 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL9IL9 isoform 1. (144 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (649 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
ACEAngiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. (1306 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
CSF3Colony stimulating factor 3 (Granulocyte). (204 aa)
ALBALB isoform 2. (609 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. (394 aa)
HPHP isoform 15. (92 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
IL6-2Interleukin 6. (234 aa)
MFGE8Milk fat globule-EGF factor 8 protein. (387 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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