STRINGSTRING
FADS2 FADS2 HPX HPX SIRT1 SIRT1 PTGS2 PTGS2 SLC16A1 SLC16A1 TMSB4X-2 TMSB4X-2 SESN2 SESN2 MFN2 MFN2 POR-2 POR-2 SIRT1-2 SIRT1-2 STAT3 STAT3 PXDN PXDN SMAD3 SMAD3 FDFT1 FDFT1 HJV HJV FXN FXN FTH1 FTH1 TIMP1 TIMP1 BMP4-2 BMP4-2 IL6-2 IL6-2 ABCC5 ABCC5 HFE HFE LIFR LIFR ENSPTRP00000078404 ENSPTRP00000078404 INS INS HMGCR HMGCR ELAVL1 ELAVL1 HMGB1 HMGB1 LPIN1 LPIN1 LEP LEP NF2 NF2 SLC3A2 SLC3A2 TNF TNF SLC46A1 SLC46A1 IL6 IL6 SLC7A11 SLC7A11 POR-3 POR-3 HP HP PCBP2 PCBP2 SMAD2 SMAD2 CYTB CYTB GCH1 GCH1 ADAM17 ADAM17 APOB APOB GPX4 GPX4 ECH1 ECH1 ACSL4 ACSL4 FTHL17 FTHL17 TLR4 TLR4 PXDNL PXDNL IDO1 IDO1 TFR2 TFR2 BMPER BMPER BMP6 BMP6 FGFR4 FGFR4 LOX LOX FBXL5 FBXL5 STEAP3 STEAP3 HAMP HAMP GDF15 GDF15 KEAP1 KEAP1 SMAD4 SMAD4 PIEZO1 PIEZO1 DHODH DHODH MT1G MT1G BMP4 BMP4 IFNG IFNG NFE2 NFE2 PRDX5 PRDX5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FADS2Fatty acid desaturase 2. (444 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
SIRT1SIRT1 isoform 2. (751 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
SLC16A1Solute carrier family 16, member 1 (Monocarboxylic acid transporter 1). (500 aa)
TMSB4X-2Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (54 aa)
SESN2SESN2 isoform 1. (480 aa)
MFN2MFN2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
POR-2NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
SIRT1-2Sirtuin 1. (751 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
PXDNPeroxidasin homolog. (1479 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (468 aa)
HJVHFE2 isoform 1. (426 aa)
FXNFXN isoform 1. (210 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
IL6-2Interleukin 6. (234 aa)
ABCC5ATP-binding cassette, sub-family C (CFTR/MRP), member 5. (1437 aa)
HFEHereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
LIFRLeukemia inhibitory factor receptor alpha. (1097 aa)
ENSPTRP00000078404annotation not available (801 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
HMGB1HMGB1 isoform 1. (215 aa)
LPIN1LPIN1 isoform 7. (975 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
SLC3A2Solute carrier family 3 member 2. (631 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
SLC46A1Solute carrier family 46 (Folate transporter), member 1. (459 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
SLC7A11Solute carrier family 7, (Cationic amino acid transporter, y+ system) member 11. (515 aa)
POR-3Cytochrome p450 oxidoreductase. (660 aa)
HPHP isoform 15. (92 aa)
PCBP2Poly(rC) binding protein 2. (366 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (380 aa)
GCH1GTP cyclohydrolase 1. (250 aa)
ADAM17ADAM17 isoform 3. (999 aa)
APOBAPOB isoform 1. (4562 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (233 aa)
ECH1Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial isoform X1. (328 aa)
ACSL4Acyl-CoA synthetase long-chain family member 4. (749 aa)
FTHL17Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
PXDNLPXDNL isoform 2. (1463 aa)
IDO1IDO1 isoform 2. (403 aa)
TFR2Transferrin receptor 2. (801 aa)
BMPERBMP binding endothelial regulator. (685 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
LOXLOX isoform 1. (417 aa)
FBXL5F-box and leucine-rich repeat protein 5. (691 aa)
STEAP3STEAP3 metalloreductase. (498 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
GDF15Growth differentiation factor 15. (308 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2516 aa)
DHODHDihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa)
MT1GMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
NFE2Nuclear factor, erythroid 2. (373 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (214 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (34%) [HD]