STRINGSTRING
NFIA NFIA CTCF CTCF HARS1 HARS1 PPP1R17 PPP1R17 GLI3 GLI3 GPC4 GPC4 CK820_G0018745 CK820_G0018745 GLI2 GLI2 TBR1 TBR1 SOX2 SOX2 EN1 EN1 ATOH1 ATOH1 ZNF333 ZNF333 RELN RELN PAX6 PAX6 ZNF333-2 ZNF333-2 MEF2A MEF2A NPAS3 NPAS3 RBPJ RBPJ AUTS2 AUTS2 PTBP2 PTBP2 CUX1 CUX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFIANuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (554 aa)
CTCFCCCTC-binding factor (Zinc finger protein). (727 aa)
HARS1HARS isoform 1. (509 aa)
PPP1R17Protein phosphatase 1 regulatory subunit 17. (155 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
GPC4GPC4 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
CK820_G0018745FZD8 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (628 aa)
GLI2GLI family zinc finger 2. (1587 aa)
TBR1T-box brain transcription factor 1. (682 aa)
SOX2SRY-box transcription factor 2. (319 aa)
EN1Homeobox protein engrailed-like. (396 aa)
ATOH1Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). (356 aa)
ZNF333Zinc finger protein 333. (666 aa)
RELNRELN isoform 3. (3460 aa)
PAX6PAX6 isoform 13. (436 aa)
ZNF333-2Zinc finger protein 333. (666 aa)
MEF2AMyocyte enhancer factor 2A. (507 aa)
NPAS3NPAS3 isoform 1. (937 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1259 aa)
PTBP2Polypyrimidine tract binding protein 2. (543 aa)
CUX1Homeobox protein cut-like. (1515 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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