STRINGSTRING
KRAS KRAS CNTNAP2 CNTNAP2 ZIC4 ZIC4 ZIC1 ZIC1 SHH SHH DISC1 DISC1 ETV2 ETV2 BMP4-2 BMP4-2 HSF1 HSF1 SNCA SNCA INSC INSC TSC2 TSC2 DBH DBH TRH TRH BMP7 BMP7 BMP4 BMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
ZIC4Zic family member 4. (384 aa)
ZIC1Zic family member 1. (447 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
DISC1Disrupted in schizophrenia 1 protein isoform X1. (977 aa)
ETV2ETV2 isoform 5. (370 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
HSF1Heat shock transcription factor 1. (529 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
INSCINSC spindle orientation adaptor protein. (579 aa)
TSC2Tuberous sclerosis 2. (1689 aa)
DBHDopamine beta-hydroxylase. (617 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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