38 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAX8	PAX8 isoform 1. (456 aa)
	CD44	CD44 isoform 3. (742 aa)
	MBP	Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). (304 aa)
	STAT2	Signal transducer and activator of transcription. (851 aa)
	AIRE	Autoimmune regulator. (545 aa)
	EP300	E1A binding protein p300. (2175 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
	CDCP1	CUB domain containing protein 1. (836 aa)
	RHOA	Ras homolog family member A. (193 aa)
	GNAI2	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
	POU5F1	POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). (360 aa)
	GATAD1	GATA zinc finger domain containing 1. (270 aa)
	KLF4	Kruppel-like factor 4 (Gut). (479 aa)
	PLP1	Proteolipid protein 1. (277 aa)
	ARRB1	ARRB1 isoform 1. (418 aa)
	SOX2	SRY-box transcription factor 2. (319 aa)
	PRDM9	PRDM9 isoform 1. (725 aa)
	CD22-2	B-cell receptor CD22. (626 aa)
	FOXO3	FOXO3 isoform 1. (673 aa)
	CDK1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	PAXIP1	PAX interacting protein 1. (1067 aa)
	PDE4B	Phosphodiesterase. (736 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
	MEIS1	MEIS1 isoform 7. (465 aa)
	KDM5C	Lysine (K)-specific demethylase 5C. (1560 aa)
	KMT2E	Myeloid/lymphoid or mixed-lineage leukemia 5. (1877 aa)
	MEF2A	Myocyte enhancer factor 2A. (507 aa)
	ING5	Inhibitor of growth family member 5. (254 aa)
	PIAS2	Protein inhibitor of activated STAT, 2. (621 aa)
	CREBBP	CREB binding protein. (2442 aa)
	PVALB	PVALB isoform 1; Belongs to the parvalbumin family. (110 aa)
	POU2F1	POU domain protein. (766 aa)
	ENSPTRP00000077785	annotation not available (270 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	MOG	Myelin oligodendrocyte glycoprotein. (295 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (347 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIRE	CREBBP	ENSPTRP00000024049	ENSPTRP00000074980	Autoimmune regulator.	CREB binding protein.	0.595
ARRB1	EP300	ENSPTRP00000043134	ENSPTRP00000024841	ARRB1 isoform 1.	E1A binding protein p300.	0.578
ARRB1	MAPK3	ENSPTRP00000043134	ENSPTRP00000053615	ARRB1 isoform 1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.978
ARRB1	RHOA	ENSPTRP00000043134	ENSPTRP00000025759	ARRB1 isoform 1.	Ras homolog family member A.	0.601
CD22-2	MBP	ENSPTRP00000048802	ENSPTRP00000091696	B-cell receptor CD22.	Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).	0.895
CD22-2	MOG	ENSPTRP00000048802	ENSPTRP00000080071	B-cell receptor CD22.	Myelin oligodendrocyte glycoprotein.	0.822
CD22-2	PLP1	ENSPTRP00000048802	ENSPTRP00000038073	B-cell receptor CD22.	Proteolipid protein 1.	0.721
CD22-2	RHOA	ENSPTRP00000048802	ENSPTRP00000025759	B-cell receptor CD22.	Ras homolog family member A.	0.590
CD44	CDK1	ENSPTRP00000090745	ENSPTRP00000050657	CD44 isoform 3.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.470
CD44	EGR1	ENSPTRP00000090745	ENSPTRP00000084676	CD44 isoform 3.	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.	0.495
CD44	FOS	ENSPTRP00000090745	ENSPTRP00000078496	CD44 isoform 3.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.489
CD44	KLF4	ENSPTRP00000090745	ENSPTRP00000036269	CD44 isoform 3.	Kruppel-like factor 4 (Gut).	0.524
CD44	MAPK3	ENSPTRP00000090745	ENSPTRP00000053615	CD44 isoform 3.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.591
CD44	RHOA	ENSPTRP00000090745	ENSPTRP00000025759	CD44 isoform 3.	Ras homolog family member A.	0.621
CD44	RUNX2	ENSPTRP00000090745	ENSPTRP00000065999	CD44 isoform 3.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.636
CD44	SOX2	ENSPTRP00000090745	ENSPTRP00000046752	CD44 isoform 3.	SRY-box transcription factor 2.	0.602
CDCP1	GNAI2	ENSPTRP00000025573	ENSPTRP00000025802	CUB domain containing protein 1.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	0.603
CDK1	CD44	ENSPTRP00000050657	ENSPTRP00000090745	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	CD44 isoform 3.	0.470
CDK1	CREBBP	ENSPTRP00000050657	ENSPTRP00000074980	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	CREB binding protein.	0.582
CDK1	EP300	ENSPTRP00000050657	ENSPTRP00000024841	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	E1A binding protein p300.	0.637