12 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NCOA3	Nuclear receptor coactivator. (1426 aa)
	EP300	E1A binding protein p300. (2175 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	ATXN3	ATXN3 isoform 4. (374 aa)
	TPR	Translocated promoter region (To activated MET oncogene). (2363 aa)
	ATXN1	ATXN1 isoform 2. (827 aa)
	HTT	HTT isoform 1. (3131 aa)
	CREBBP	CREB binding protein. (2442 aa)
	USP7	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1121 aa)
	AR	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
	ATXN7	ATXN7 isoform 2. (939 aa)
	PQBP1	Polyglutamine binding protein 1. (265 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CREBBP	ENSPTRP00000076864	ENSPTRP00000074980	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	CREB binding protein.	0.910
AR	EP300	ENSPTRP00000076864	ENSPTRP00000024841	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	E1A binding protein p300.	0.919
AR	HTT	ENSPTRP00000076864	ENSPTRP00000065166	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	HTT isoform 1.	0.522
AR	NCOA3	ENSPTRP00000076864	ENSPTRP00000023375	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Nuclear receptor coactivator.	0.988
ATXN1	ATXN3	ENSPTRP00000057036	ENSPTRP00000044008	ATXN1 isoform 2.	ATXN3 isoform 4.	0.763
ATXN1	HTT	ENSPTRP00000057036	ENSPTRP00000065166	ATXN1 isoform 2.	HTT isoform 1.	0.777
ATXN1	PQBP1	ENSPTRP00000057036	ENSPTRP00000087496	ATXN1 isoform 2.	Polyglutamine binding protein 1.	0.755
ATXN1	USP7	ENSPTRP00000057036	ENSPTRP00000075972	ATXN1 isoform 2.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.445
ATXN3	ATXN1	ENSPTRP00000044008	ENSPTRP00000057036	ATXN3 isoform 4.	ATXN1 isoform 2.	0.763
ATXN3	ATXN7	ENSPTRP00000044008	ENSPTRP00000085607	ATXN3 isoform 4.	ATXN7 isoform 2.	0.891
ATXN3	CREBBP	ENSPTRP00000044008	ENSPTRP00000074980	ATXN3 isoform 4.	CREB binding protein.	0.606
ATXN3	EP300	ENSPTRP00000044008	ENSPTRP00000024841	ATXN3 isoform 4.	E1A binding protein p300.	0.446
ATXN3	HTT	ENSPTRP00000044008	ENSPTRP00000065166	ATXN3 isoform 4.	HTT isoform 1.	0.695
ATXN3	USP7	ENSPTRP00000044008	ENSPTRP00000075972	ATXN3 isoform 4.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.462
ATXN3	VCP	ENSPTRP00000044008	ENSPTRP00000035748	ATXN3 isoform 4.	Valosin containing protein; Belongs to the AAA ATPase family.	0.990
ATXN7	ATXN3	ENSPTRP00000085607	ENSPTRP00000044008	ATXN7 isoform 2.	ATXN3 isoform 4.	0.891
ATXN7	HTT	ENSPTRP00000085607	ENSPTRP00000065166	ATXN7 isoform 2.	HTT isoform 1.	0.509
CREBBP	AR	ENSPTRP00000074980	ENSPTRP00000076864	CREB binding protein.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.910
CREBBP	ATXN3	ENSPTRP00000074980	ENSPTRP00000044008	CREB binding protein.	ATXN3 isoform 4.	0.606
CREBBP	EP300	ENSPTRP00000074980	ENSPTRP00000024841	CREB binding protein.	E1A binding protein p300.	0.999