STRINGSTRING
FOXG1 FOXG1 CASP3 CASP3 ALB ALB APLP1 APLP1 SOX1 SOX1 WNT7B WNT7B DLL3 DLL3 WNT7A WNT7A PAX6 PAX6 DCX DCX FGF2 FGF2 BCL6 BCL6 CDON CDON LRP5 LRP5 FOXP2 FOXP2 CLN8 CLN8 JAG2 JAG2 JUND JUND ASCL1 ASCL1 FOS FOS SATB2 SATB2 NHLH1 NHLH1 CDKN2B CDKN2B NEUROG2 NEUROG2 ENSPTRP00000086254 ENSPTRP00000086254 MOXD1 MOXD1 DKK3 DKK3 PXDN PXDN FABP7 FABP7 APP APP GAPDH GAPDH ACSBG1 ACSBG1 MAPT MAPT ALPK2 ALPK2 GAPDHS GAPDHS APLP2 APLP2 FZD5 FZD5 EGF EGF PXDNL PXDNL TCF4 TCF4 SETX SETX SOX2 SOX2 PTPRZ1 PTPRZ1 DNER DNER APCDD1 APCDD1 KREMEN1 KREMEN1 WNT3A WNT3A NES NES DKK1 DKK1 EMX2 EMX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXG1FOXG1 isoform 8. (489 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
ALBALB isoform 2. (609 aa)
APLP1APLP1 isoform 2. (650 aa)
SOX1SOX1 isoform 1. (391 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
PAX6PAX6 isoform 13. (436 aa)
DCXDCX isoform 5. (420 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
BCL6BCL6 transcription repressor. (706 aa)
CDONCell adhesion associated, oncogene regulated. (1286 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
FOXP2Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). (741 aa)
CLN8Ceroid-lipofuscinosis neuronal protein 8. (286 aa)
JAG2Jagged canonical Notch ligand 2. (1130 aa)
JUNDJUND isoform 1. (346 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SATB2DNA-binding protein SATB. (733 aa)
NHLH1Nescient helix-loop-helix 1. (133 aa)
CDKN2BCyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa)
NEUROG2NEUROG2 isoform 1. (272 aa)
ENSPTRP00000086254Microtubule-associated protein tau. (776 aa)
MOXD1MOXD1 isoform 1. (613 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (413 aa)
PXDNPeroxidasin homolog. (1479 aa)
FABP7Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (166 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (724 aa)
MAPTMicrotubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabili [...] (776 aa)
ALPK2ALPK2 isoform 1. (2171 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (408 aa)
APLP2Amyloid beta precursor like protein 2. (761 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
PXDNLPXDNL isoform 2. (1463 aa)
TCF4Transcription factor 4. (773 aa)
SETXSETX isoform 1. (2668 aa)
SOX2SRY-box transcription factor 2. (319 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2315 aa)
DNERDelta/notch-like EGF repeat containing. (739 aa)
APCDD1Adenomatosis polyposis coli down-regulated 1. (514 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1620 aa)
DKK1Dickkopf-like protein 1. (289 aa)
EMX2Empty spiracles homeobox 2. (252 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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