STRINGSTRING
SOX3 SOX3 TFAP2B TFAP2B LHX8 LHX8 FGF2 FGF2 NUBP2 NUBP2 TUBB3 TUBB3 FOXD3 FOXD3 TWIST1 TWIST1 PHOX2A PHOX2A BARX1 BARX1 SOX2 SOX2 SOX10 SOX10 ISL1 ISL1 EGF EGF DLX2 DLX2 SOX9 SOX9 DLX3 DLX3 CTCF CTCF TCF12 TCF12 PRRX1 PRRX1 ALX3 ALX3 INS INS ALX4 ALX4 LHX6 LHX6 NR2F1 NR2F1 PAX3 PAX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX3SRY-box transcription factor 3. (446 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
LHX8LHX8 isoform 2. (377 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (270 aa)
TUBB3Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (797 aa)
FOXD3FOXD3 isoform 1. (478 aa)
TWIST1TWIST1 isoform 2. (163 aa)
PHOX2APaired like homeobox 2A. (284 aa)
BARX1BARX homeobox 1. (254 aa)
SOX2SRY-box transcription factor 2. (319 aa)
SOX10SRY-box transcription factor 10. (466 aa)
ISL1ISL LIM homeobox 1. (349 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
DLX2Distal-less homeobox 2. (328 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
DLX3Distal-less homeobox 3. (287 aa)
CTCFCCCTC-binding factor (Zinc finger protein). (727 aa)
TCF12Transcription factor 12. (706 aa)
PRRX1Paired related homeobox 1. (245 aa)
ALX3ALX homeobox 3. (343 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
ALX4ALX homeobox 4. (411 aa)
LHX6LHX6 isoform 3. (428 aa)
NR2F1Nuclear receptor subfamily 2 group F member 1. (423 aa)
PAX3PAX3 isoform 4. (505 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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