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LTBP4 LTBP4 MASP2 MASP2 LRP8 LRP8 THBS3 THBS3 HMCN1 HMCN1 NID1 NID1 CUBN CUBN OIT3 OIT3 NELL1 NELL1 LTBP3 LTBP3 EFEMP2 EFEMP2 F10 F10 NID2 NID2 CCBE1 CCBE1 ADGRE1 ADGRE1 NOTCH3 NOTCH3 NCAN NCAN MEGF8 MEGF8 FBLN7 FBLN7 LRP1B LRP1B LRP2 LRP2 SNED1 SNED1 JAG1 JAG1 THBD THBD CD93 CD93 PROS1 PROS1 HEG1 HEG1 EGF EGF THBS4 THBS4 VCAN VCAN SLIT3 SLIT3 DLL1 DLL1 BMP1 BMP1 HMCN2 HMCN2 NOTCH1 NOTCH1 EGFL7 EGFL7 CRB2 CRB2 EGFL6 EGFL6 CRB1 CRB1 LTBP1 LTBP1 F9 F9 DNER DNER ADGRE5 ADGRE5 FBN3 FBN3 SUSD1 SUSD1 SVEP1 SVEP1 VLDLR VLDLR DLK2 DLK2 C1R C1R C1S C1S CRELD2 CRELD2 SCUBE3 SCUBE3 COMP COMP NOTCH4 NOTCH4 FAT4 FAT4 CD248 CD248 FBLN1 FBLN1 LOC460532 LOC460532 ADGRE2 ADGRE2 PROC PROC FAT1 FAT1 LTBP2 LTBP2 NELL2 NELL2 FBN1 FBN1 EFEMP1 EFEMP1 FAT3 FAT3 MEGF6 MEGF6 SCUBE1 SCUBE1 F10-2 F10-2 LRP1 LRP1 MATN2 MATN2 F7 F7 FBLN5 FBLN5 VWCE VWCE ENSPTRP00000074765 ENSPTRP00000074765 LDLR LDLR TLL1 TLL1 ADGRE3 ADGRE3 NOTCH2 NOTCH2 JAG2 JAG2 TPO TPO UMOD UMOD SLIT2 SLIT2 TLL2 TLL2 ADGRL4 ADGRL4 CRELD1 CRELD1 LRP4 LRP4 SLIT1 SLIT1 SCUBE2 SCUBE2 MASP1 MASP1 ENSPTRP00000084287 ENSPTRP00000084287 ENSPTRP00000085552 ENSPTRP00000085552 EDIL3 EDIL3 NPNT NPNT CELSR2 CELSR2 EYS EYS ADGRE5-2 ADGRE5-2 FBLN2 FBLN2 ENSPTRP00000091509 ENSPTRP00000091509 FBN2 FBN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LTBP4Latent transforming growth factor beta binding protein 4. (1622 aa)
MASP2Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa)
LRP8LDL receptor related protein 8. (960 aa)
THBS3Thrombospondin 3. (956 aa)
HMCN1HMCN1 isoform 1. (5635 aa)
NID1NID1 isoform 2. (1247 aa)
CUBNCUBN isoform 1. (3623 aa)
OIT3OIT3 isoform 1. (545 aa)
NELL1Neural EGFL like 1. (838 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
EFEMP2EGF containing fibulin-like extracellular matrix protein 2. (443 aa)
F10Coagulation factor X. (488 aa)
NID2Nidogen 2 (Osteonidogen). (1375 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
ADGRE1ADGRE1 isoform 4; Belongs to the G-protein coupled receptor 2 family. (941 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
NCANNeurocan core protein; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N- CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid (By similarity); Belongs to the aggrecan/versican proteoglycan family. (1321 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
FBLN7FBLN7 isoform 1. (439 aa)
LRP1BLDL receptor related protein 1B. (4599 aa)
LRP2LRP2 isoform 1. (4655 aa)
SNED1Sushi, nidogen and EGF-like domains 1. (1405 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
THBDTHBD isoform 1. (631 aa)
CD93CD93 isoform 1. (650 aa)
PROS1Protein S (Alpha). (676 aa)
HEG1HEG1 isoform 1. (1381 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
THBS4THBS4 isoform 3. (961 aa)
VCANVCAN isoform 3. (3396 aa)
SLIT3SLIT3 isoform 2. (1459 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
BMP1Metalloendopeptidase. (986 aa)
HMCN2HMCN2 isoform 1. (5060 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
EGFL7EGF-like-domain, multiple 7. (273 aa)
CRB2CRB2 isoform 1. (1285 aa)
EGFL6EGF-like-domain, multiple 6. (553 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1719 aa)
F9Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family. (466 aa)
DNERDelta/notch-like EGF repeat containing. (739 aa)
ADGRE5Adhesion G protein-coupled receptor E5; Belongs to the G-protein coupled receptor 2 family. (840 aa)
FBN3FBN3 isoform 1. (2809 aa)
SUSD1SUSD1 isoform 1. (757 aa)
SVEP1Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3571 aa)
VLDLRVery low density lipoprotein receptor. (874 aa)
DLK2Delta like non-canonical Notch ligand 2. (383 aa)
C1RComplement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family. (719 aa)
C1SComplement component 1, s subcomponent; Belongs to the peptidase S1 family. (780 aa)
CRELD2CRELD2 isoform 1. (402 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (993 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
FAT4FAT tumor suppressor homolog 4. (4983 aa)
CD248CD248 molecule, endosialin. (757 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (721 aa)
LOC460532LOW QUALITY PROTEIN: vitamin K-dependent protein S-like. (638 aa)
ADGRE2Adhesion G protein-coupled receptor E2; Belongs to the G-protein coupled receptor 2 family. (833 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (495 aa)
FAT1FAT tumor suppressor homolog 1. (4600 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1821 aa)
NELL2Neural EGFL like 2. (839 aa)
FBN1FBN1 isoform 1. (2871 aa)
EFEMP1EGF-containing fibulin-like extracellular matrix protein 1. (493 aa)
FAT3FAT3 isoform 2. (4612 aa)
MEGF6MEGF6 isoform 2. (1503 aa)
SCUBE1Signal peptide, CUB domain and EGF like domain containing 1. (988 aa)
F10-2Coagulation factor X. (475 aa)
LRP1LDL receptor related protein 1. (4544 aa)
MATN2MATN2 isoform 2. (956 aa)
F7Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity). Belongs to the peptidase S1 family. (454 aa)
FBLN5FBLN5 isoform 2. (489 aa)
VWCEVon Willebrand factor C and EGF domains. (955 aa)
ENSPTRP00000074765annotation not available (537 aa)
LDLRLDLR isoform 7. (917 aa)
TLL1Metalloendopeptidase. (1036 aa)
ADGRE3Adhesion G protein-coupled receptor E3; Belongs to the G-protein coupled receptor 2 family. (652 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
JAG2Jagged canonical Notch ligand 2. (1130 aa)
TPOTPO isoform 5. (847 aa)
UMODUMOD isoform 1. (690 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
TLL2Metalloendopeptidase. (1015 aa)
ADGRL4EGF, latrophilin and seven transmembrane domain containing 1; Belongs to the G-protein coupled receptor 2 family. (691 aa)
CRELD1Cysteine-rich with EGF-like domains 1. (420 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
SCUBE2SCUBE2 isoform 2. (996 aa)
MASP1Mannan binding lectin serine peptidase 1. (699 aa)
ENSPTRP00000084287annotation not available (136 aa)
ENSPTRP00000085552annotation not available (686 aa)
EDIL3EGF-like repeats and discoidin I-like domains 3. (480 aa)
NPNTNPNT isoform 10. (611 aa)
CELSR2CELSR2 isoform 1; Belongs to the G-protein coupled receptor 2 family. (2925 aa)
EYSEYS isoform 1. (3144 aa)
ADGRE5-2Adhesion G protein-coupled receptor E5. (854 aa)
FBLN2FBLN2 isoform 1. (1231 aa)
ENSPTRP00000091509annotation not available (387 aa)
FBN2FBN2 isoform 1. (2912 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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