STRINGSTRING
HSPG2 HSPG2 MATN1 MATN1 TIE1 TIE1 LRP8 LRP8 THBS3 THBS3 PEAR1 PEAR1 SELP SELP SELL SELL TNN TNN HMCN1 HMCN1 PTGS2 PTGS2 BRINP3 BRINP3 NID1 NID1 CUBN CUBN OIT3 OIT3 PLAU PLAU HABP2 HABP2 NELL1 NELL1 LTBP3 LTBP3 EFEMP2 EFEMP2 TENM4 TENM4 TECTA-2 TECTA-2 SORL1 SORL1 LRP6 LRP6 WIF1 WIF1 F10 F10 PROZ PROZ NAGPA NAGPA IMPG1 IMPG1 ADAM28 ADAM28 ADAM9 ADAM9 TMEFF2 TMEFF2 NRG1 NRG1 NTNG2 NTNG2 FBN2 FBN2 ENSPTRP00000091509 ENSPTRP00000091509 LOC459608 LOC459608 ADAM22-2 ADAM22-2 ENSPTRP00000089337 ENSPTRP00000089337 LOC467971 LOC467971 FBLN2 FBLN2 MUC4 MUC4 EYS EYS CELSR2 CELSR2 NPNT NPNT CK820_G0006908 CK820_G0006908 EGFLAM EGFLAM EDIL3 EDIL3 ITGB8-2 ITGB8-2 ENSPTRP00000084287 ENSPTRP00000084287 SCUBE2 SCUBE2 SLIT1 SLIT1 MFGE8 MFGE8 LOC467495 LOC467495 CSPG5 CSPG5 ADAM23 ADAM23 ITGB8 ITGB8 LRP4 LRP4 PTGS1 PTGS1 CRELD1 CRELD1 ADGRL4 ADGRL4 NTNG1 NTNG1 MEP1B MEP1B NRG4 NRG4 ADAM32 ADAM32 DLK1 DLK1 CELSR3 CELSR3 SLIT2 SLIT2 CNTNAP4 CNTNAP4 TGFA TGFA PROZ-2 PROZ-2 ASTN1 ASTN1 NRXN2 NRXN2 UMOD UMOD ENSPTRP00000076730 ENSPTRP00000076730 JAG2 JAG2 ENSPTRP00000075867 ENSPTRP00000075867 NOTCH2 NOTCH2 LDLR LDLR ENSPTRP00000074950 ENSPTRP00000074950 VWCE VWCE HGFAC-2 HGFAC-2 NRXN1 NRXN1 F7 F7 MATN2 MATN2 HGFAC HGFAC THBS2 THBS2 NRG3 NRG3 LRP1 LRP1 F10-2 F10-2 SCUBE1 SCUBE1 DLL4 DLL4 MEGF6 MEGF6 TEK TEK ADAM33 ADAM33 ZAN ZAN CK820_G0051040 CK820_G0051040 LRP5 LRP5 FAT3 FAT3 FBN1 FBN1 NELL2 NELL2 ENSPTRP00000067006 ENSPTRP00000067006 LTBP2 LTBP2 FAT1 FAT1 THBS1 THBS1 PAMR1 PAMR1 SCARF2 SCARF2 ADAM8 ADAM8 CNTNAP2 CNTNAP2 PROC PROC DLL3 DLL3 ADAM2 ADAM2 SELE SELE LOC460532 LOC460532 TMEFF1 TMEFF1 FBLN1 FBLN1 MEP1A MEP1A AREG AREG CD248 CD248 ADAM11 ADAM11 FAT4 FAT4 CELSR1 CELSR1 NOTCH4 NOTCH4 MEGF11 MEGF11 COMP COMP RELN RELN TMEM8B TMEM8B SCUBE3 SCUBE3 CRELD2 CRELD2 ADAM22 ADAM22 VWA2 VWA2 TMEM8A TMEM8A VASN VASN CNTNAP1 CNTNAP1 BCAN BCAN ITGB5 ITGB5 MALRD1 MALRD1 LOC462578 LOC462578 DLK2 DLK2 STAB2 STAB2 VLDLR VLDLR SVEP1 SVEP1 SUSD1 SUSD1 FBN3 FBN3 DNER DNER HYAL4 HYAL4 F9 F9 HYAL2 HYAL2 ITGBL1 ITGBL1 LTBP1 LTBP1 CRB1 CRB1 NRXN3 NRXN3 EGFL6 EGFL6 NRG2 NRG2 CLEC14A CLEC14A CRB2 CRB2 AGRN AGRN ADAM15 ADAM15 ATRNL1 ATRNL1 BRINP2 BRINP2 TENM1 TENM1 EGFL7 EGFL7 NOTCH1 NOTCH1 TNC TNC CNTNAP3 CNTNAP3 PLAT PLAT VWDE VWDE DLL1 DLL1 LAMA2 LAMA2 RSPO3 RSPO3 F12 F12 SLIT3 SLIT3 TENM2 TENM2 FAT2 FAT2 HBEGF HBEGF MEGF10 MEGF10 VCAN VCAN THBS4 THBS4 TENM3 TENM3 HHIP HHIP EGF EGF MMRN1 MMRN1 BTC BTC EREG EREG EPGN EPGN HEG1 HEG1 MUC13 MUC13 PROS1 PROS1 STAB1 STAB1 HYAL1 HYAL1 HYAL3 HYAL3 TDGF1 TDGF1 UMODL1 UMODL1 MATN4 MATN4 CD93 CD93 THBD THBD JAG1 JAG1 ATRN ATRN SNED1 SNED1 LRP2 LRP2 LRP1B LRP1B CNTNAP5 CNTNAP5 FBLN7 FBLN7 ATRAID ATRAID MATN3 MATN3 MEGF8 MEGF8 LTBP4 LTBP4 NCAN NCAN NOTCH3 NOTCH3 ADGRE1 ADGRE1 CCBE1 CCBE1 GPR179 GPR179 SCARF1 SCARF1 NID2 NID2 ACAN ACAN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HSPG2HSPG2 isoform 1. (4390 aa)
MATN1MATN1 isoform 1. (496 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
LRP8LDL receptor related protein 8. (960 aa)
THBS3Thrombospondin 3. (956 aa)
PEAR1Platelet endothelial aggregation receptor 1. (1037 aa)
SELPSELP isoform 2. (830 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia; Belongs to the selectin/LECAM family. (385 aa)
TNNTNN isoform 1. (1299 aa)
HMCN1HMCN1 isoform 1. (5635 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
BRINP3BMP/retinoic acid inducible neural specific 3. (766 aa)
NID1NID1 isoform 2. (1247 aa)
CUBNCUBN isoform 1. (3623 aa)
OIT3OIT3 isoform 1. (545 aa)
PLAUPlasminogen activator, urokinase. (431 aa)
HABP2Hyaluronan binding protein 2. (560 aa)
NELL1Neural EGFL like 1. (838 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
EFEMP2EGF containing fibulin-like extracellular matrix protein 2. (443 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
TECTA-2TECTA isoform 2. (2155 aa)
SORL1Sortilin related receptor 1. (2214 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
WIF1WNT inhibitory factor 1. (379 aa)
F10Coagulation factor X. (488 aa)
PROZProtein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family. (422 aa)
NAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (515 aa)
IMPG1IMPG1 isoform 1. (800 aa)
ADAM28ADAM28 isoform 1. (797 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
TMEFF2Transmembrane protein with EGF-like and two follistatin-like domains 2. (374 aa)
NRG1NRG1 isoform 3. (713 aa)
NTNG2NTNG2 isoform 1. (530 aa)
FBN2FBN2 isoform 1. (2912 aa)
ENSPTRP00000091509annotation not available (387 aa)
LOC459608CFC1B isoform 2. (223 aa)
ADAM22-2ADAM22 isoform 3. (923 aa)
ENSPTRP00000089337annotation not available (2012 aa)
LOC467971Disintegrin and metalloproteinase domain-containing protein 21-like. (633 aa)
FBLN2FBLN2 isoform 1. (1231 aa)
MUC4MUC4 isoform 10. (1084 aa)
EYSEYS isoform 1. (3144 aa)
CELSR2CELSR2 isoform 1; Belongs to the G-protein coupled receptor 2 family. (2925 aa)
NPNTNPNT isoform 10. (611 aa)
CK820_G0006908TNXB isoform 2. (3702 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (1017 aa)
EDIL3EGF-like repeats and discoidin I-like domains 3. (480 aa)
ITGB8-2Integrin subunit beta 8. (780 aa)
ENSPTRP00000084287annotation not available (136 aa)
SCUBE2SCUBE2 isoform 2. (996 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
MFGE8Milk fat globule-EGF factor 8 protein. (387 aa)
LOC467495Disintegrin and metalloproteinase domain-containing protein 20-like. (738 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (566 aa)
ADAM23ADAM metallopeptidase domain 23. (832 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
PTGS1Prostaglandin-endoperoxide synthase 1 (Prostaglandin G/H synthase and cyclooxygenase). (599 aa)
CRELD1Cysteine-rich with EGF-like domains 1. (420 aa)
ADGRL4EGF, latrophilin and seven transmembrane domain containing 1; Belongs to the G-protein coupled receptor 2 family. (691 aa)
NTNG1NTNG1 isoform 2. (540 aa)
MEP1BMeprin A subunit. (701 aa)
NRG4NRG4 isoform 3. (117 aa)
ADAM32ADAM metallopeptidase domain 32. (787 aa)
DLK1Delta like non-canonical Notch ligand 1. (383 aa)
CELSR3Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family. (3322 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
CNTNAP4Contactin associated protein like 4. (1308 aa)
TGFATGFA isoform 6. (193 aa)
PROZ-2Protein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family. (400 aa)
ASTN1ASTN1 isoform 3. (1294 aa)
NRXN2NRXN2 isoform 2. (1712 aa)
UMODUMOD isoform 1. (690 aa)
ENSPTRP00000076730annotation not available (2837 aa)
JAG2Jagged canonical Notch ligand 2. (1130 aa)
ENSPTRP00000075867annotation not available (618 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
LDLRLDLR isoform 7. (917 aa)
ENSPTRP00000074950annotation not available (707 aa)
VWCEVon Willebrand factor C and EGF domains. (955 aa)
HGFAC-2HGFAC isoform 3. (662 aa)
NRXN1NRXN1 isoform 9. (1547 aa)
F7Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity). Belongs to the peptidase S1 family. (454 aa)
MATN2MATN2 isoform 2. (956 aa)
HGFACHGFAC isoform 1. (655 aa)
THBS2Thrombospondin 2. (1107 aa)
NRG3NRG3 isoform 3. (721 aa)
LRP1LDL receptor related protein 1. (4544 aa)
F10-2Coagulation factor X. (475 aa)
SCUBE1Signal peptide, CUB domain and EGF like domain containing 1. (988 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
MEGF6MEGF6 isoform 2. (1503 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
ADAM33ADAM metallopeptidase domain 33. (813 aa)
ZANZAN isoform 1. (2659 aa)
CK820_G0051040EYS isoform 4. (318 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
FAT3FAT3 isoform 2. (4612 aa)
FBN1FBN1 isoform 1. (2871 aa)
NELL2Neural EGFL like 2. (839 aa)
ENSPTRP00000067006Disintegrin and metalloproteinase domain-containing protein 21-like. (718 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1821 aa)
FAT1FAT tumor suppressor homolog 1. (4600 aa)
THBS1Thrombospondin 1. (1173 aa)
PAMR1Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family. (737 aa)
SCARF2Scavenger receptor class F member 2 isoform X1. (871 aa)
ADAM8ADAM metallopeptidase domain 8. (824 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (495 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
ADAM2ADAM2 isoform 1. (735 aa)
SELESELE isoform 1. (612 aa)
LOC460532LOW QUALITY PROTEIN: vitamin K-dependent protein S-like. (638 aa)
TMEFF1Transmembrane protein with EGF like and two follistatin like domains 1. (454 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (721 aa)
MEP1AMeprin A subunit. (753 aa)
AREGAREG isoform 2. (274 aa)
CD248CD248 molecule, endosialin. (757 aa)
ADAM11ADAM metallopeptidase domain 11. (774 aa)
FAT4FAT tumor suppressor homolog 4. (4983 aa)
CELSR1CELSR1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (2998 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
MEGF11Multiple EGF like domains 11. (1140 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
RELNRELN isoform 3. (3460 aa)
TMEM8BTransmembrane protein 8B. (472 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (993 aa)
CRELD2CRELD2 isoform 1. (402 aa)
ADAM22ADAM metallopeptidase domain 22. (906 aa)
VWA2VWA2 isoform 1. (755 aa)
TMEM8ATMEM8A isoform 1. (772 aa)
VASNVASN isoform 1. (673 aa)
CNTNAP1Contactin associated protein 1. (1384 aa)
BCANBCAN isoform 2. (907 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
MALRD1MALRD1 isoform 3. (1867 aa)
LOC462578TNXB isoform 1. (4244 aa)
DLK2Delta like non-canonical Notch ligand 2. (383 aa)
STAB2STAB2 isoform 1. (2551 aa)
VLDLRVery low density lipoprotein receptor. (874 aa)
SVEP1Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3571 aa)
SUSD1SUSD1 isoform 1. (757 aa)
FBN3FBN3 isoform 1. (2809 aa)
DNERDelta/notch-like EGF repeat containing. (739 aa)
HYAL4Hyaluronidase. (476 aa)
F9Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family. (466 aa)
HYAL2Hyaluronidase. (473 aa)
ITGBL1Integrin, beta-like 1 (With EGF-like repeat domains). (494 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1719 aa)
CRB1Crumbs cell polarity complex component 1. (1406 aa)
NRXN3NRXN3 isoform 1. (1664 aa)
EGFL6EGF-like-domain, multiple 6. (553 aa)
NRG2NRG2 isoform 3. (859 aa)
CLEC14AC-type lectin domain containing 14A. (490 aa)
CRB2CRB2 isoform 1. (1285 aa)
AGRNAGRN isoform 2. (2066 aa)
ADAM15ADAM metallopeptidase domain 15. (863 aa)
ATRNL1ATRNL1 isoform 1. (1379 aa)
BRINP2BMP/retinoic acid inducible neural specific 2. (783 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
EGFL7EGF-like-domain, multiple 7. (273 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
TNCTNC isoform 1. (2201 aa)
CNTNAP3CNTNAP3 isoform 2. (1167 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (649 aa)
VWDEVWDE isoform 1. (1591 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
RSPO3RSPO3 isoform 1. (292 aa)
F12Coagulation factor XII. (615 aa)
SLIT3SLIT3 isoform 2. (1459 aa)
TENM2Teneurin transmembrane protein 2. (2774 aa)
FAT2FAT atypical cadherin 2. (4349 aa)
HBEGFHeparin-binding EGF-like growth factor. (208 aa)
MEGF10MEGF10 isoform 2. (1140 aa)
VCANVCAN isoform 3. (3396 aa)
THBS4THBS4 isoform 3. (961 aa)
TENM3Teneurin transmembrane protein 3. (2699 aa)
HHIPHedgehog interacting protein. (700 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
MMRN1MMRN1 isoform 1. (1229 aa)
BTCBTC isoform 1. (178 aa)
EREGEREG isoform 1. (169 aa)
EPGNEpithelial mitogen. (154 aa)
HEG1HEG1 isoform 1. (1381 aa)
MUC13Mucin 13, cell surface associated. (496 aa)
PROS1Protein S (Alpha). (676 aa)
STAB1STAB1 isoform 1. (2570 aa)
HYAL1Hyaluronidase. (435 aa)
HYAL3Hyaluronidase-3 precursor. (417 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
UMODL1UMODL1 isoform 3. (1445 aa)
MATN4MATN4 isoform 4. (622 aa)
CD93CD93 isoform 1. (650 aa)
THBDTHBD isoform 1. (631 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ATRNATRN isoform 1. (1429 aa)
SNED1Sushi, nidogen and EGF-like domains 1. (1405 aa)
LRP2LRP2 isoform 1. (4655 aa)
LRP1BLDL receptor related protein 1B. (4599 aa)
CNTNAP5CNTNAP5 isoform 2. (1307 aa)
FBLN7FBLN7 isoform 1. (439 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (284 aa)
MATN3MATN3 isoform 1. (486 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1622 aa)
NCANNeurocan core protein; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N- CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid (By similarity); Belongs to the aggrecan/versican proteoglycan family. (1321 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
ADGRE1ADGRE1 isoform 4; Belongs to the G-protein coupled receptor 2 family. (941 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
GPR179GPR179 isoform 2. (2365 aa)
SCARF1Scavenger receptor class F, member 1. (830 aa)
NID2Nidogen 2 (Osteonidogen). (1375 aa)
ACANACAN isoform 1. (2319 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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