(30 nodes) Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNS1	TNS1 isoform 5. (1740 aa)
	APBB2	Amyloid beta precursor protein binding family B member 2. (768 aa)
	APBA2	Amyloid beta precursor protein binding family A member 2. (751 aa)
	APBB3	Amyloid beta (A4) protein-binding, family B, member 3. (601 aa)
	RABGAP1L	PID domain-containing protein. (815 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	ANKS1A	Ankyrin repeat and sterile alpha motif domain containing 1A. (1140 aa)
	APBB1	APBB1 isoform 4. (772 aa)
	DAB2	Disabled homolog 2, mitogen-responsive phosphoprotein. (770 aa)
	NUMBL	NUMBL isoform 1. (611 aa)
	SHC3	SHC3 isoform 2. (598 aa)
	TNS2	TNS2 isoform 7. (1419 aa)
	DAB1	DAB adaptor protein 1. (588 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
	MAPK8IP2	MAPK8IP2 isoform 2. (824 aa)
	ANKS1B	Ankyrin repeat and sterile alpha motif domain containing 1B. (1248 aa)
	NUMB	NUMB endocytic adaptor protein. (651 aa)
	GULP1	GULP, engulfment adaptor PTB domain containing 1. (304 aa)
	TNS3	TNS3 isoform 2. (1445 aa)
	NOS1AP	Nitric oxide synthase 1 adaptor protein. (506 aa)
	RABGAP1	Rab GTPase-activating protein 1 isoform X1. (1085 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (837 aa)
	TBC1D1	TBC1 (Tre-2/USP6, BUB2, cdc16) domain family, member 1. (1168 aa)
	RGS12	Regulator of G-protein signaling 12. (1447 aa)
	APBA3	Amyloid beta precursor protein binding family A member 3. (575 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	TBC1D4	TBC1D4 isoform 2. (1298 aa)
	EPS8	Epidermal growth factor receptor pathway substrate 8. (822 aa)
	MAPK8IP1	Mitogen-activated protein kinase 8 interacting protein 1. (711 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (308 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBA1	APBB1	ENSPTRP00000035905	ENSPTRP00000074196	Amyloid beta precursor protein binding family A member 1.	APBB1 isoform 4.	0.643
APBA1	APBB2	ENSPTRP00000035905	ENSPTRP00000089147	Amyloid beta precursor protein binding family A member 1.	Amyloid beta precursor protein binding family B member 2.	0.632
APBA2	APBB1	ENSPTRP00000086587	ENSPTRP00000074196	Amyloid beta precursor protein binding family A member 2.	APBB1 isoform 4.	0.595
APBA2	APBB2	ENSPTRP00000086587	ENSPTRP00000089147	Amyloid beta precursor protein binding family A member 2.	Amyloid beta precursor protein binding family B member 2.	0.660
APBB1	APBA1	ENSPTRP00000074196	ENSPTRP00000035905	APBB1 isoform 4.	Amyloid beta precursor protein binding family A member 1.	0.643
APBB1	APBA2	ENSPTRP00000074196	ENSPTRP00000086587	APBB1 isoform 4.	Amyloid beta precursor protein binding family A member 2.	0.595
APBB1	APBB2	ENSPTRP00000074196	ENSPTRP00000089147	APBB1 isoform 4.	Amyloid beta precursor protein binding family B member 2.	0.796
APBB1	DAB1	ENSPTRP00000074196	ENSPTRP00000052263	APBB1 isoform 4.	DAB adaptor protein 1.	0.438
APBB1	MAPK8IP1	ENSPTRP00000074196	ENSPTRP00000006140	APBB1 isoform 4.	Mitogen-activated protein kinase 8 interacting protein 1.	0.568
APBB1	SHC1	ENSPTRP00000074196	ENSPTRP00000051735	APBB1 isoform 4.	SHC (Src homology 2 domain containing) transforming protein 1.	0.401
APBB2	APBA1	ENSPTRP00000089147	ENSPTRP00000035905	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family A member 1.	0.632
APBB2	APBA2	ENSPTRP00000089147	ENSPTRP00000086587	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family A member 2.	0.660
APBB2	APBB1	ENSPTRP00000089147	ENSPTRP00000074196	Amyloid beta precursor protein binding family B member 2.	APBB1 isoform 4.	0.796
DAB1	APBB1	ENSPTRP00000052263	ENSPTRP00000074196	DAB adaptor protein 1.	APBB1 isoform 4.	0.438
DAB2	LDLRAP1	ENSPTRP00000071697	ENSPTRP00000000643	Disabled homolog 2, mitogen-responsive phosphoprotein.	Low density lipoprotein receptor adaptor protein 1.	0.491
LDLRAP1	DAB2	ENSPTRP00000000643	ENSPTRP00000071697	Low density lipoprotein receptor adaptor protein 1.	Disabled homolog 2, mitogen-responsive phosphoprotein.	0.491
MAPK8IP1	APBB1	ENSPTRP00000006140	ENSPTRP00000074196	Mitogen-activated protein kinase 8 interacting protein 1.	APBB1 isoform 4.	0.568
MAPK8IP1	MAPK8IP2	ENSPTRP00000006140	ENSPTRP00000049579	Mitogen-activated protein kinase 8 interacting protein 1.	MAPK8IP2 isoform 2.	0.989
MAPK8IP2	MAPK8IP1	ENSPTRP00000049579	ENSPTRP00000006140	MAPK8IP2 isoform 2.	Mitogen-activated protein kinase 8 interacting protein 1.	0.989
NUMB	NUMBL	ENSPTRP00000045621	ENSPTRP00000063782	NUMB endocytic adaptor protein.	NUMBL isoform 1.	0.944