31 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SEMA6A	SEMA6A isoform 2; Belongs to the semaphorin family. (1047 aa)
	ENSPTRP00000087014	annotation not available (777 aa)
	SEMA3B	SEMA3B isoform 2; Belongs to the semaphorin family. (749 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
	SEMA6D	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6D; Belongs to the semaphorin family. (1086 aa)
	SEMA3F	SEMA3F isoform 2; Belongs to the semaphorin family. (785 aa)
	PLXNB2	PLXNB2 isoform 1. (1838 aa)
	SEMA4G	SEMA4G isoform 3; Belongs to the semaphorin family. (843 aa)
	SEMA4A	SEMA4A isoform 10; Belongs to the semaphorin family. (761 aa)
	SEMA3E	SEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
	PLXNA4	PLXNA4 isoform 1. (1894 aa)
	SEMA4D	SEMA4D isoform 13; Belongs to the semaphorin family. (862 aa)
	SEMA4F	SEMA4F isoform 1; Belongs to the semaphorin family. (770 aa)
	PLXNA3	PLXNA3 isoform 1. (1871 aa)
	SEMA3D	SEMA3D isoform 1; Belongs to the semaphorin family. (777 aa)
	SEMA3A	SEMA3A isoform 1; Belongs to the semaphorin family. (771 aa)
	SEMA3C	SEMA3C isoform 1; Belongs to the semaphorin family. (751 aa)
	SEMA5A	SEMA5A isoform 1. (1074 aa)
	PLXND1	PLXND1 isoform 1. (1925 aa)
	SEMA5B	SEMA5B isoform 1. (1352 aa)
	SEMA3G	SEMA3G isoform 2; Belongs to the semaphorin family. (782 aa)
	MST1R	Macrophage stimulating 1 receptor. (1400 aa)
	PLXNB1	PLXNB1 isoform 1. (2135 aa)
	SEMA4C	SEMA4C isoform 2; Belongs to the semaphorin family. (833 aa)
	SEMA6B	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6B; Belongs to the semaphorin family. (888 aa)
	SEMA4B	SEMA4B isoform 1; Belongs to the semaphorin family. (836 aa)
	SEMA7A	SEMA7A isoform 1; Belongs to the semaphorin family. (664 aa)
	PLXNA2	PLXNA2 isoform 1. (1909 aa)
	SEMA6C	SEMA6C isoform 2; Belongs to the semaphorin family. (962 aa)
	PLXNB3	PLXNB3 isoform 1. (1932 aa)
	PLXNA1	PLXNA1 isoform 1. (1915 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPTRP00000087014	MET	ENSPTRP00000087014	ENSPTRP00000083162	annotation not available	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.609
ENSPTRP00000087014	MST1R	ENSPTRP00000087014	ENSPTRP00000025788	annotation not available	Macrophage stimulating 1 receptor.	0.609
ENSPTRP00000087014	PLXNA1	ENSPTRP00000087014	ENSPTRP00000088978	annotation not available	PLXNA1 isoform 1.	0.625
ENSPTRP00000087014	PLXNA2	ENSPTRP00000087014	ENSPTRP00000003263	annotation not available	PLXNA2 isoform 1.	0.402
ENSPTRP00000087014	PLXNA3	ENSPTRP00000087014	ENSPTRP00000038678	annotation not available	PLXNA3 isoform 1.	0.679
ENSPTRP00000087014	PLXNA4	ENSPTRP00000087014	ENSPTRP00000059933	annotation not available	PLXNA4 isoform 1.	0.543
ENSPTRP00000087014	PLXNB1	ENSPTRP00000087014	ENSPTRP00000025675	annotation not available	PLXNB1 isoform 1.	0.433
ENSPTRP00000087014	PLXNB3	ENSPTRP00000087014	ENSPTRP00000092121	annotation not available	PLXNB3 isoform 1.	0.451
ENSPTRP00000087014	PLXND1	ENSPTRP00000087014	ENSPTRP00000026498	annotation not available	PLXND1 isoform 1.	0.642
MET	ENSPTRP00000087014	ENSPTRP00000083162	ENSPTRP00000087014	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	annotation not available	0.609
MET	MST1R	ENSPTRP00000083162	ENSPTRP00000025788	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Macrophage stimulating 1 receptor.	0.738
MET	PLXNA1	ENSPTRP00000083162	ENSPTRP00000088978	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	PLXNA1 isoform 1.	0.410
MET	PLXNA2	ENSPTRP00000083162	ENSPTRP00000003263	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	PLXNA2 isoform 1.	0.410
MET	PLXNA3	ENSPTRP00000083162	ENSPTRP00000038678	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	PLXNA3 isoform 1.	0.410
MET	PLXNA4	ENSPTRP00000083162	ENSPTRP00000059933	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	PLXNA4 isoform 1.	0.410
MET	PLXNB1	ENSPTRP00000083162	ENSPTRP00000025675	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	PLXNB1 isoform 1.	0.997
MET	PLXNB2	ENSPTRP00000083162	ENSPTRP00000077349	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	PLXNB2 isoform 1.	0.966
MET	PLXNB3	ENSPTRP00000083162	ENSPTRP00000092121	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	PLXNB3 isoform 1.	0.969
MET	PLXND1	ENSPTRP00000083162	ENSPTRP00000026498	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	PLXND1 isoform 1.	0.410
MET	SEMA3A	ENSPTRP00000083162	ENSPTRP00000033105	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	SEMA3A isoform 1; Belongs to the semaphorin family.	0.627