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| | NCK2 | Cytoplasmic protein. (380 aa) |
| | ERRFI1 | ERBB receptor feedback inhibitor 1. (462 aa) |
| | EPS15 | Epidermal growth factor receptor pathway substrate 15. (896 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | PKN2 | Protein kinase N2. (984 aa) |
| | NRAS | Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa) |
| | ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1). (431 aa) |
| | SHOC2 | SHOC2 leucine rich repeat scaffold protein. (582 aa) |
| | HRAS | V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa) |
| | PTPN5 | Protein tyrosine phosphatase non-receptor type 5. (565 aa) |
| | INPPL1 | Inositol polyphosphate phosphatase-like 1. (1258 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (553 aa) |
| | ZPR1 | Zinc finger protein 259. (459 aa) |
| | CBL | Cas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa) |
| | EPS8 | Epidermal growth factor receptor pathway substrate 8. (822 aa) |
| | ATF1 | Activating transcription factor 1. (270 aa) |
| | KRT18 | KRT18 isoform 1; Belongs to the intermediate filament family. (430 aa) |
| | SP1 | Sp1 transcription factor. (786 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa) |
| | PEBP1 | Phosphatidylethanolamine binding protein 1. (187 aa) |
| | FOXO1 | FOXO1 isoform 1. (655 aa) |
| | MAP2K5 | Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa) |
| | CSK | Tyrosine-protein kinase. (450 aa) |
| | SH3GL3 | SH3 domain containing GRB2 like 3, endophilin A3. (355 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (211 aa) |
| | PLD2 | Phospholipase. (933 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa) |
| | KRT17 | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] (432 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | TGIF1 | Homeobox protein TGIF1; Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activitie [...] (401 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) |
| | EPS15L1 | Epidermal growth factor receptor pathway substrate 15 like 1. (910 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa) |
| | RFXANK | Regulatory factor X-associated ankyrin-containing protein. (260 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | KLF11 | Kruppel-like factor 11. (512 aa) |
| | MAP3K2 | Mitogen-activated protein kinase kinase kinase 2. (619 aa) |
| | GRB14 | Growth factor receptor-bound protein 14. (540 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | RAB5A | RAB5A, member RAS oncogene family. (216 aa) |
| | APPL1 | Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (709 aa) |
| | ARF4 | ADP-ribosylation factor 4; Belongs to the small GTPase superfamily. Arf family. (180 aa) |
| | CBLB | Cas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa) |
| | NCK1 | Cytoplasmic protein. (377 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa) |
| | GAB1 | GRB2-associated-binding protein 1. (724 aa) |
| | RASA1 | RAS p21 protein activator (GTPase activating protein) 1. (1047 aa) |
| | DUSP1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa) |
| | RIPK1 | Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa) |
| | MAPK14 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa) |
| | REPS1 | RALBP1 associated Eps domain containing 1. (796 aa) |
| | PTPN12 | Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (780 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | WASL | WASP like actin nucleation promoting factor. (505 aa) |
| | DOK2 | Docking protein 2. (412 aa) |
| | PTK2B | PTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1129 aa) |
| | PLEC | PLEC isoform 2. (4684 aa) |
| | SH2D3C | SH2 domain containing 3C. (860 aa) |
| | RALGDS | Ral guanine nucleotide dissociation stimulator. (914 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | PLD1 | Phospholipase. (1074 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa) |
| | ABI1 | Abl interactor 1. (508 aa) |
| | GAB2 | GRB2-associated-binding protein 2. (676 aa) |
| | EEF1A1 | Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa) |
| | PRKAR1A | Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1). (381 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | RBBP7 | RBBP7 isoform 5. (469 aa) |
| | MAP3K1 | MAP3K1 isoform 1. (1509 aa) |
| | RALBP1 | RalA binding protein 1. (655 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | PLSCR1 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (318 aa) |
| | SHC1 | SHC (Src homology 2 domain containing) transforming protein 1. (584 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | SH3BGRL | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (114 aa) |
| | GRB10 | Growth factor receptor-bound protein 10. (594 aa) |
| | GIT1 | G protein-coupled receptor kinase interacting ArfGAP 1. (770 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa) |
| | PITPNA | Phosphatidylinositol transfer protein, alpha. (276 aa) |
| | PTPRR | Protein tyrosine phosphatase receptor type R. (657 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa) |
| | HTT | HTT isoform 1. (3131 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (802 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa) |
| | AP2A1 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa) |
| | SNRPD2 | Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | GRB7 | Growth factor receptor bound protein 7. (555 aa) |
| | REPS2 | RALBP1 associated Eps domain containing 2. (659 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | RALB | V-ral simian leukemia viral oncogene homolog B (Ras related GTP binding protein). (212 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (438 aa) |
| | PXN-2 | PXN isoform 9. (1081 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa) |
| | USP6NL | USP6NL isoform 4. (851 aa) |
| | TNIP1 | TNIP1 isoform 12. (645 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa) |
| | ELF3 | E74 like ETS transcription factor 3. (375 aa) |
| | CDC42 | Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (916 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1. (352 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | JAK2 | Tyrosine-protein kinase. (1143 aa) |
| | PIK3C2B | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa) |
| | SH3KBP1 | SH3KBP1 isoform 2. (665 aa) |
| | AKT1 | AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa) |
| | CRK | V-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa) |
| | KRAS | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (347 aa) |
| | CTNND1 | CTNND1 isoform 23. (975 aa) |
| | CASP9 | CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa) |
| | VAV3 | VAV3 isoform 2. (927 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (442 aa) |
| | SNCA | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa) |
| | STAT1 | Signal transducer and activator of transcription. (758 aa) |
| | STAT3 | Signal transducer and activator of transcription. (790 aa) |
| | KRT7 | Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells; Belongs to the intermediate filament family. (469 aa) |
| | STAT2 | Signal transducer and activator of transcription. (851 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3. (225 aa) |
