STRINGSTRING
ID3 ID3 RXRG RXRG GTF3A GTF3A CYP26B1 CYP26B1 NRIP1 NRIP1 ZMPSTE24 ZMPSTE24 NR1H3 NR1H3 KLF6 KLF6 E2F4 E2F4 LIFR LIFR INS INS RETN RETN PPARG PPARG SREBF1 SREBF1 GATA4 GATA4 HMGA1 HMGA1 MEF2D MEF2D DVL1 DVL1 LPIN1 LPIN1 CREB1 CREB1 LEP LEP GADD45B GADD45B MIXL1 MIXL1 MEF2A MEF2A RBL2 RBL2 NCOA2 NCOA2 IL6 IL6 IGF1 IGF1 IL6ST IL6ST GATA3 GATA3 KLF7 KLF7 KLF5 KLF5 CEBPD CEBPD GATA2 GATA2 FOXC2 FOXC2 RARA RARA GADD45A GADD45A AGPAT2 AGPAT2 NAMPT NAMPT RXRA RXRA CTNNB1 CTNNB1 CYP26A1 CYP26A1 PPARD PPARD DDIT3 DDIT3 GDF10 GDF10 PLIN2 PLIN2 BMP1 BMP1 LPL LPL SERPINE1 SERPINE1 SFRP4 SFRP4 AHR AHR EBF1 EBF1 NR3C1 NR3C1 SPOCK1 SPOCK1 PRLR PRLR UCP1 UCP1 BMP3 BMP3 ADIPOQ ADIPOQ PPARA PPARA OSM OSM LIF LIF PCK1 PCK1 RBL1 RBL1 ASIP ASIP BMP2 BMP2 IRS1 IRS1 FRZB FRZB EPAS1 EPAS1 NCOA1 NCOA1 TGFB1 TGFB1 LPIN2 LPIN2 SOCS1 SOCS1 PLIN1 PLIN1 HIF1A HIF1A PCK2 PCK2 IRS2 IRS2 RB1 RB1 FOXO1 FOXO1 SP1 SP1 WNT1 WNT1 WNT10B WNT10B WNT5B WNT5B SCD SCD EGR2 EGR2 AGT AGT LMNA LMNA MBNL1 MBNL1 PTGIS PTGIS CEBPB CEBPB CCND1 CCND1 RORA RORA FZD1 FZD1 FAS FAS NR2F1 NR2F1 NCOR2 NCOR2 MEF2C MEF2C SMAD3 SMAD3 MIF MIF STAT1 STAT1 BORCS8 BORCS8 STAT3 STAT3 STAT2 STAT2 SOCS3 SOCS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ID3Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. (119 aa)
RXRGRetinoid X receptor gamma. (473 aa)
GTF3AGTF3A isoform 1. (410 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
NRIP1Nuclear receptor interacting protein 1. (1158 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
KLF6Kruppel-like factor 6. (302 aa)
E2F4E2F transcription factor 4, p107/p130-binding. (414 aa)
LIFRLeukemia inhibitory factor receptor alpha. (1097 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
RETNRETN isoform 1. (108 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
GATA4GATA binding protein 4. (443 aa)
HMGA1High mobility group protein HMG-I/HMG-Y. (201 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa)
LPIN1LPIN1 isoform 7. (975 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
GADD45BGrowth arrest and DNA-damage-inducible, beta. (160 aa)
MIXL1Mix paired-like homeobox. (232 aa)
MEF2AMyocyte enhancer factor 2A. (507 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
IL6STInterleukin 6 signal transducer (Gp130, oncostatin M receptor). (918 aa)
GATA3GATA binding protein 3. (444 aa)
KLF7Kruppel-like factor 7 (Ubiquitous). (302 aa)
KLF5Kruppel-like factor 5 (Intestinal). (457 aa)
CEBPDCCAAT/enhancer-binding protein. (269 aa)
GATA2GATA binding protein 2. (480 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
RARARARA isoform 4. (624 aa)
GADD45AGrowth arrest and DNA-damage-inducible, alpha. (165 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (279 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
RXRARetinoid X receptor, alpha. (462 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
PLIN2Perilipin; Belongs to the perilipin family. (445 aa)
BMP1Metalloendopeptidase. (986 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
SFRP4SFRP4 isoform 1. (368 aa)
AHRT0073207 isoform 1. (850 aa)
EBF1EBF transcription factor 1. (591 aa)
NR3C1NR3C1 isoform 5. (778 aa)
SPOCK1Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (Testican) 1. (439 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
OSMOSM isoform 1. (252 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
ASIPAgouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). (132 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
FRZBFrizzled-related protein. (325 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LPIN2LPIN2 isoform 2. (896 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
PLIN1Perilipin; Belongs to the perilipin family. (522 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
IRS2IRS2 isoform 1. (1340 aa)
RB1RB transcriptional corepressor 1. (928 aa)
FOXO1FOXO1 isoform 1. (655 aa)
SP1Sp1 transcription factor. (786 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
SCDStearoyl-CoA desaturase (Delta-9-desaturase); Belongs to the fatty acid desaturase type 1 family. (359 aa)
EGR2Early growth response 2. (476 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
LMNALMNA isoform 8; Belongs to the intermediate filament family. (664 aa)
MBNL1Muscleblind like splicing regulator 1. (400 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
RORARAR-related orphan receptor A. (555 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
FASFas (TNF receptor superfamily, member 6). (337 aa)
NR2F1Nuclear receptor subfamily 2 group F member 1. (423 aa)
NCOR2Nuclear receptor corepressor 2. (2514 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
BORCS8BORCS8 isoform 3. (161 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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