STRINGSTRING
RB1 RB1 ID3 ID3 LMNA LMNA AGT AGT EGR2 EGR2 SCD SCD WNT5B WNT5B WNT10B WNT10B WNT1 WNT1 SP1 SP1 FOXO1 FOXO1 IRS2 IRS2 PCK2 PCK2 HIF1A HIF1A PLIN1 PLIN1 SOCS1 SOCS1 LPIN2 LPIN2 TGFB1 TGFB1 NCOA1 NCOA1 EPAS1 EPAS1 FRZB FRZB IRS1 IRS1 BMP2 BMP2 ASIP ASIP RBL1 RBL1 PCK1 PCK1 LIF LIF OSM OSM PPARA PPARA ADIPOQ ADIPOQ BMP3 BMP3 UCP1 UCP1 PRLR PRLR SPOCK1 SPOCK1 NR3C1 NR3C1 EBF1 EBF1 AHR AHR SFRP4 SFRP4 SERPINE1 SERPINE1 LPL LPL BMP1 BMP1 PLIN2 PLIN2 GDF10 GDF10 DDIT3 DDIT3 PPARD PPARD CYP26A1 CYP26A1 CTNNB1 CTNNB1 RXRA RXRA NAMPT NAMPT AGPAT2 AGPAT2 GADD45A GADD45A RARA RARA FOXC2 FOXC2 GATA2 GATA2 CEBPD CEBPD KLF5 KLF5 KLF7 KLF7 GATA3 GATA3 IL6ST IL6ST IGF1 IGF1 IL6 IL6 NCOA2 NCOA2 RBL2 RBL2 MEF2A MEF2A MIXL1 MIXL1 GADD45B GADD45B LEP LEP CREB1 CREB1 LPIN1 LPIN1 DVL1 DVL1 MEF2D MEF2D HMGA1 HMGA1 GATA4 GATA4 SREBF1 SREBF1 PPARG PPARG RETN RETN INS INS LIFR LIFR E2F4 E2F4 KLF6 KLF6 NR1H3 NR1H3 ZMPSTE24 ZMPSTE24 NRIP1 NRIP1 CYP26B1 CYP26B1 RXRG RXRG MBNL1 MBNL1 PTGIS PTGIS CEBPB CEBPB CCND1 CCND1 RORA RORA FZD1 FZD1 FAS FAS NR2F1 NR2F1 NCOR2 NCOR2 MEF2C MEF2C SMAD3 SMAD3 MIF MIF STAT1 STAT1 BORCS8 BORCS8 STAT3 STAT3 STAT2 STAT2 SOCS3 SOCS3 GTF3A GTF3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RB1RB transcriptional corepressor 1. (928 aa)
ID3Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. (119 aa)
LMNALMNA isoform 8; Belongs to the intermediate filament family. (664 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
EGR2Early growth response 2. (476 aa)
SCDStearoyl-CoA desaturase (Delta-9-desaturase); Belongs to the fatty acid desaturase type 1 family. (359 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SP1Sp1 transcription factor. (786 aa)
FOXO1FOXO1 isoform 1. (655 aa)
IRS2IRS2 isoform 1. (1340 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PLIN1Perilipin; Belongs to the perilipin family. (522 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
LPIN2LPIN2 isoform 2. (896 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
FRZBFrizzled-related protein. (325 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
ASIPAgouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). (132 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
OSMOSM isoform 1. (252 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
SPOCK1Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (Testican) 1. (439 aa)
NR3C1NR3C1 isoform 5. (778 aa)
EBF1EBF transcription factor 1. (591 aa)
AHRT0073207 isoform 1. (850 aa)
SFRP4SFRP4 isoform 1. (368 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
BMP1Metalloendopeptidase. (986 aa)
PLIN2Perilipin; Belongs to the perilipin family. (445 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
RXRARetinoid X receptor, alpha. (462 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (279 aa)
GADD45AGrowth arrest and DNA-damage-inducible, alpha. (165 aa)
RARARARA isoform 4. (624 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
GATA2GATA binding protein 2. (480 aa)
CEBPDCCAAT/enhancer-binding protein. (269 aa)
KLF5Kruppel-like factor 5 (Intestinal). (457 aa)
KLF7Kruppel-like factor 7 (Ubiquitous). (302 aa)
GATA3GATA binding protein 3. (444 aa)
IL6STInterleukin 6 signal transducer (Gp130, oncostatin M receptor). (918 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
MEF2AMyocyte enhancer factor 2A. (507 aa)
MIXL1Mix paired-like homeobox. (232 aa)
GADD45BGrowth arrest and DNA-damage-inducible, beta. (160 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LPIN1LPIN1 isoform 7. (975 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
HMGA1High mobility group protein HMG-I/HMG-Y. (201 aa)
GATA4GATA binding protein 4. (443 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
RETNRETN isoform 1. (108 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (200 aa)
LIFRLeukemia inhibitory factor receptor alpha. (1097 aa)
E2F4E2F transcription factor 4, p107/p130-binding. (414 aa)
KLF6Kruppel-like factor 6. (302 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
NRIP1Nuclear receptor interacting protein 1. (1158 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
RXRGRetinoid X receptor gamma. (473 aa)
MBNL1Muscleblind like splicing regulator 1. (400 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
RORARAR-related orphan receptor A. (555 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
FASFas (TNF receptor superfamily, member 6). (337 aa)
NR2F1Nuclear receptor subfamily 2 group F member 1. (423 aa)
NCOR2Nuclear receptor corepressor 2. (2514 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
BORCS8BORCS8 isoform 3. (161 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
GTF3AGTF3A isoform 1. (410 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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