STRINGSTRING
MAP2K1 MAP2K1 PDK1 PDK1 PTPRU PTPRU SRC SRC JAK2 JAK2 CISH CISH STAT1 STAT1 AKT1 AKT1 PTPRC PTPRC IRS2 IRS2 SOCS1 SOCS1 GRB2 GRB2 MAP2K2 MAP2K2 IRS1 IRS1 MAPK1 MAPK1 RASA1 RASA1 EPO EPO PIK3CG PIK3CG EPOR EPOR SHC1 SHC1 SOS1 SOS1 MAPK3 MAPK3 STAT3 STAT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
PDK1Protein-serine/threonine kinase. (456 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1454 aa)
SRCTyrosine-protein kinase. (542 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
CISHCytokine inducible SH2 containing protein. (275 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1306 aa)
IRS2IRS2 isoform 1. (1340 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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