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| | NFKB2 | Nuclear factor kappa B subunit 2. (900 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | RAP1A | RAP1A, member of RAS oncogene family. (184 aa) |
| | KRAS | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (760 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (796 aa) |
| | CACNA1A | Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2504 aa) |
| | CRK | V-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa) |
| | MAPK13 | Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] (366 aa) |
| | AKT1 | AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | STK3 | Serine/threonine kinase 3. (519 aa) |
| | HSPA2 | Heat shock 70kDa protein 2; Belongs to the heat shock protein 70 family. (642 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa) |
| | RAPGEF2 | RAPGEF2 isoform 2. (1701 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | RASGRF1 | Ras protein specific guanine nucleotide releasing factor 1. (1273 aa) |
| | CDC42 | Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa) |
| | JUND | JUND isoform 1. (346 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (838 aa) |
| | CACNG4 | Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa) |
| | MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (837 aa) |
| | CACNA1D | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa) |
| | LOC100610002 | IKBKG isoform 9. (401 aa) |
| | DUSP2 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (314 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa) |
| | IL1R1 | Interleukin 1 receptor, type I. (569 aa) |
| | CACNA1S | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa) |
| | HSPA8 | Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (521 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (438 aa) |
| | MAP3K12 | Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa) |
| | MAP3K4 | MAP3K4 isoform 5. (1601 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa) |
| | RASGRP1 | RASGRP1 isoform 4. (848 aa) |
| | CACNA2D4 | CACNA2D4 isoform 6. (1154 aa) |
| | CACNA2D1 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa) |
| | MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (847 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (551 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2). (207 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (384 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa) |
| | TAOK2 | TAOK2 isoform 1. (1235 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | FGF13 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (503 aa) |
| | ECSIT | ECSIT signalling integrator. (431 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (802 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily, member 1A. (455 aa) |
| | CACNA1G | Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (854 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (526 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa) |
| | STK4 | Serine/threonine-protein kinase 4. (487 aa) |
| | GNG12 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | PTPRR | Protein tyrosine phosphatase receptor type R. (657 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa) |
| | DUSP3 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa) |
| | BDNF | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa) |
| | LOC745166 | HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa) |
| | LOC748548 | JmjC domain-containing protein. (330 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | CACNA1I | Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2223 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) |
| | CACNB4 | Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (370 aa) |
| | RELA | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | CFAP299 | Cilia and flagella associated protein 299. (250 aa) |
| | GADD45A | Growth arrest and DNA-damage-inducible, alpha. (165 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | CACNA2D3 | CACNA2D3 isoform 3. (1091 aa) |
| | TAOK3 | TAOK3 isoform 1. (898 aa) |
| | MAPK8IP2 | MAPK8IP2 isoform 2. (824 aa) |
| | MAP3K1 | MAP3K1 isoform 1. (1509 aa) |
| | FLNC | Filamin C, gamma. (2725 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | CACNB2 | Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1374 aa) |
| | ARRB1 | ARRB1 isoform 1. (418 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa) |
| | CDC25B | Cell division cycle 25 homolog B. (580 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | NR4A1 | Nuclear receptor subfamily 4 group A member 1. (652 aa) |
| | CACNA1F | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa) |
| | ELK1 | ELK1, member of ETS oncogene family. (428 aa) |
| | CACNA1B | Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2312 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | PRKACG | Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa) |
| | MOS | MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (346 aa) |
| | IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (763 aa) |
| | DUSP4 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa) |
| | HSPB1 | Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa) |
| | GNA12 | Guanine nucleotide binding protein (G protein) alpha 12. (381 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | SRF | Serum response factor (C-fos serum response element-binding transcription factor). (508 aa) |
| | MAPK14 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa) |
| | DAXX | Death domain associated protein. (742 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (802 aa) |
| | DUSP1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | RASA1 | RAS p21 protein activator (GTPase activating protein) 1. (1047 aa) |
| | RASGRF2 | Ras protein specific guanine nucleotide releasing factor 2. (1237 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa) |
| | NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa) |
| | LAMTOR3 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa) |
| | MAP3K13 | Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa) |
| | RASA2 | RAS p21 protein activator 2. (849 aa) |
| | MRAS | Muscle RAS oncogene homolog. (208 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | DUSP7 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa) |
| | MAPKAPK3 | Mitogen-activated protein kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa) |
| | ATF4 | Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa) |
| | RAC3 | Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3). (205 aa) |
| | CACNG2 | Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | MAP3K20 | Sterile alpha motif and leucine zipper containing kinase AZK. (803 aa) |
| | MAP3K2 | Mitogen-activated protein kinase kinase kinase 2. (619 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (271 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (398 aa) |
| | PPM1B | Protein phosphatase, Mg2+/Mn2+ dependent, 1B. (479 aa) |
| | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (894 aa) |
| | RASGRP3 | RAS guanyl releasing protein 3. (690 aa) |
| | CACNG7 | Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | RRAS | Related RAS viral (R-ras) oncogene homolog. (218 aa) |
| | NTF4 | NTF4 isoform 1; Belongs to the NGF-beta family. (210 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | PLA2G4C | Phospholipase A2 group IVC. (541 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | PRKACA | PRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | MKNK2 | MAP kinase interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | CACNG1 | Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa) |
| | CACNG5 | Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | NF1 | Neurofibromin 1. (2839 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | ARRB2 | ARRB2 isoform 2. (430 aa) |
| | CACNG3 | Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa) |
| | CACNA1H | CACNA1H isoform 1. (2240 aa) |
| | MAP2K5 | Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | PLA2G4D | Phospholipase A2. (818 aa) |
| | PLA2G4E | Phospholipase A2. (868 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | PPM1A | Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa) |
| | FGF14 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | LRRK2 | Leucine-rich repeat kinase 2. (2527 aa) |
| | DUSP16 | Dual specificity phosphatase 16. (665 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa) |
| | CACNA1C | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (553 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 isoform X2. (847 aa) |
| | RASGRP2 | RAS guanyl releasing protein 2. (609 aa) |
| | MAPK8IP1 | Mitogen-activated protein kinase 8 interacting protein 1. (711 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | PTPN5 | Protein tyrosine phosphatase non-receptor type 5. (565 aa) |
| | RRAS2 | Related RAS viral (R-ras) oncogene homolog 2. (204 aa) |
| | HRAS | V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (467 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | MAPKAPK2 | Mitogen-activated protein kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1). (431 aa) |
| | PTPN7 | Protein tyrosine phosphatase non-receptor type 7. (465 aa) |
| | PLA2G4A | Phospholipase A2. (749 aa) |
| | CACNA1E | Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa) |
| | FASLG | FASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa) |
| | NRAS | Neuroblastoma RAS viral (V-ras) oncogene homolog. (189 aa) |
| | MAP3K6 | Mitogen-activated protein kinase kinase kinase 6. (1281 aa) |
| | STMN1 | Stathmin; Belongs to the stathmin family. (174 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (508 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | PLA2G4F | Phospholipase A2. (849 aa) |
| | FGF12 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa) |
| | NTF3 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa) |
| | FGF11 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | CACNA2D2 | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1156 aa) |
| | FLNB | Filamin B, beta. (2633 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (808 aa) |
| | RELB | RELB isoform 3. (567 aa) |
| | FAS | Fas (TNF receptor superfamily, member 6). (337 aa) |
| | MAX | MYC associated factor X. (162 aa) |
| | NFATC3 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa) |
| | CACNB3 | Calcium channel, voltage-dependent, beta 3 subunit. (487 aa) |
| | DUSP10 | Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (488 aa) |
| | CACNB1 | Calcium voltage-gated channel auxiliary subunit beta 1. (626 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
