STRINGSTRING
HCK HCK INPP5D INPP5D DOK1 DOK1 PIK3R2 PIK3R2 VAV1 VAV1 SOCS6 SOCS6 GRB2 GRB2 PRKCA PRKCA SOCS1 SOCS1 FES FES SPRED1 SPRED1 KITLG KITLG CBL CBL HRAS HRAS FGR FGR CLTC CLTC STAT3 STAT3 STAT1 STAT1 YES1 YES1 MITF MITF CRK CRK AKT1 AKT1 CISH CISH SH3KBP1 SH3KBP1 JAK2 JAK2 FYN FYN PIK3R1 PIK3R1 SRC SRC GRAPL GRAPL MPDZ MPDZ SH2B2 SH2B2 TEC TEC PTPRU PTPRU GRB7 GRB7 TNFRSF10A TNFRSF10A SPRED2 SPRED2 MAP2K1 MAP2K1 SOCS4 SOCS4 SOCS5 SOCS5 PTPN11 PTPN11 GRB10 GRB10 PLCE1 PLCE1 SOS1 SOS1 SHC1 SHC1 PTPN6 PTPN6 EPOR EPOR LYN LYN PIK3CG PIK3CG BTK BTK RASA1 RASA1 STAP1 STAP1 KIT KIT CBLB CBLB EP300 EP300 CSF2RB CSF2RB MAPK1 MAPK1 PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HCKTyrosine-protein kinase. (526 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
DOK1Docking protein 1, 62kDa (Downstream of tyrosine kinase 1). (481 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
SPRED1Sprouty-related, EVH1 domain containing 1. (444 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
FGRTyrosine-protein kinase. (529 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
YES1Tyrosine-protein kinase. (558 aa)
MITFMITF isoform 1. (519 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CISHCytokine inducible SH2 containing protein. (275 aa)
SH3KBP1SH3KBP1 isoform 2. (665 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
SRCTyrosine-protein kinase. (542 aa)
GRAPLGRAP isoform 4. (100 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2084 aa)
SH2B2Uncharacterized protein. (677 aa)
TECTyrosine-protein kinase. (631 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1454 aa)
GRB7Growth factor receptor bound protein 7. (555 aa)
TNFRSF10ATumor necrosis factor receptor superfamily, member 10a. (469 aa)
SPRED2SPRED2 isoform 3. (432 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
GRB10Growth factor receptor-bound protein 10. (594 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)
LYNTyrosine-protein kinase. (512 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
BTKBTK isoform 2. (693 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
EP300E1A binding protein p300. (2175 aa)
CSF2RBColony stimulating factor 2 receptor, beta, low-affinity (Granulocyte-macrophage). (904 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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