31 items (Pan troglodytes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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	BCL2	BCL2 apoptosis regulator. (239 aa)
	CASP9	CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
	FAS	Fas (TNF receptor superfamily, member 6). (337 aa)
	FAF1	Fas (TNFRSF6) associated factor 1. (650 aa)
	CASP6	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (293 aa)
	CFLAR	CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
	CASP7	CASP7 isoform 1; Belongs to the peptidase C14A family. (388 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
	SPTAN1	SPTAN1 isoform 9. (2498 aa)
	DFFB	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase). (338 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
	MAP3K1	MAP3K1 isoform 1. (1509 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family. (4128 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
	DAXX	Death domain associated protein. (742 aa)
	MAPKAPK3	Mitogen-activated protein kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
	CASP8	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (271 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
	RB1	RB transcriptional corepressor 1. (928 aa)
	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta. (201 aa)
	PAK1	Non-specific serine/threonine protein kinase. (553 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	MAPKAPK2	Mitogen-activated protein kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	FASLG	FASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
	LMNA	LMNA isoform 8; Belongs to the intermediate filament family. (664 aa)
	DFFA	DNA fragmentation factor subunit alpha. (331 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BCL2	ENSPTRP00000042795	ENSPTRP00000090293	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.953
APAF1	CASP3	ENSPTRP00000042795	ENSPTRP00000054330	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.997
APAF1	CASP6	ENSPTRP00000042795	ENSPTRP00000080795	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.838
APAF1	CASP7	ENSPTRP00000042795	ENSPTRP00000074501	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP7 isoform 1; Belongs to the peptidase C14A family.	0.908
APAF1	CASP8	ENSPTRP00000042795	ENSPTRP00000021879	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.914
APAF1	CASP9	ENSPTRP00000042795	ENSPTRP00000089496	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.999
APAF1	CFLAR	ENSPTRP00000042795	ENSPTRP00000078536	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family.	0.799
APAF1	DFFA	ENSPTRP00000042795	ENSPTRP00000000259	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	DNA fragmentation factor subunit alpha.	0.461
APAF1	DFFB	ENSPTRP00000042795	ENSPTRP00000064348	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	DNAation factor, 40kDa, beta polypeptide (Caspase-activated DNase).	0.469
APAF1	FADD	ENSPTRP00000042795	ENSPTRP00000006883	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.670
APAF1	FAS	ENSPTRP00000042795	ENSPTRP00000088261	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas (TNF receptor superfamily, member 6).	0.470
APAF1	FASLG	ENSPTRP00000042795	ENSPTRP00000002815	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	FASLG isoform 1; Belongs to the tumor necrosis factor family.	0.620
APAF1	HSPB1	ENSPTRP00000042795	ENSPTRP00000033044	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	0.520
APAF1	RIPK2	ENSPTRP00000042795	ENSPTRP00000069317	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.503
APAF1	TNF	ENSPTRP00000042795	ENSPTRP00000069905	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.544
BCL2	APAF1	ENSPTRP00000090293	ENSPTRP00000042795	BCL2 apoptosis regulator.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.953
BCL2	CASP3	ENSPTRP00000090293	ENSPTRP00000054330	BCL2 apoptosis regulator.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.895
BCL2	CASP6	ENSPTRP00000090293	ENSPTRP00000080795	BCL2 apoptosis regulator.	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.611
BCL2	CASP7	ENSPTRP00000090293	ENSPTRP00000074501	BCL2 apoptosis regulator.	CASP7 isoform 1; Belongs to the peptidase C14A family.	0.743
BCL2	CASP8	ENSPTRP00000090293	ENSPTRP00000021879	BCL2 apoptosis regulator.	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.906