STRINGSTRING
PTCH2 PTCH2 IGF2 IGF2 SUFU SUFU RAB23 RAB23 CREBBP CREBBP SHH SHH GAS1 GAS1 SAP18 SAP18 STK36 STK36 IHH IHH DYRK1A DYRK1A HHIP HHIP CCNB1 CCNB1 GLI3 GLI3 SMO SMO GLI2 GLI2 SIN3A SIN3A CDK1 CDK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTCH2PTCH2 isoform 3. (1203 aa)
IGF2Insulin like growth factor 2. (236 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
CREBBPCREB binding protein. (2442 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
GAS1Growth arrest-specific 1. (370 aa)
SAP18Sin3A associated protein 18. (172 aa)
STK36Serine/threonine kinase 36. (1315 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
DYRK1ADual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A. (763 aa)
HHIPHedgehog interacting protein. (700 aa)
CCNB1CCNB1 isoform 1; Belongs to the cyclin family. (433 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
GLI2GLI family zinc finger 2. (1587 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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