STRINGSTRING
HSPB1 HSPB1 PLA2G4A PLA2G4A MAPKAPK2 MAPKAPK2 TGFB2 TGFB2 HRAS HRAS MAP3K9 MAP3K9 MAP2K4 MAP2K4 GRB2 GRB2 RIPK1 RIPK1 DAXX DAXX MAPK14 MAPK14 TRAF2 TRAF2 ELK1 ELK1 MAP3K5 MAP3K5 DDIT3 DDIT3 TRADD TRADD MAP3K1 MAP3K1 SHC1 SHC1 MAP3K7 MAP3K7 MAP2K6 MAP2K6 HMGN1 HMGN1 ATF2 ATF2 RPS6KA5 RPS6KA5 CREB1 CREB1 TGFBR1 TGFBR1 MEF2D MEF2D MYC MYC CDC42 CDC42 RASGRF1 RASGRF1 MAX MAX STAT1 STAT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
PLA2G4APhospholipase A2. (749 aa)
MAPKAPK2Mitogen-activated protein kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
MAP3K9MAP3K9 isoform 3. (1119 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
DAXXDeath domain associated protein. (742 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
ELK1ELK1, member of ETS oncogene family. (428 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
TRADDTNFRSF1A-associated via death domain. (312 aa)
MAP3K1MAP3K1 isoform 1. (1509 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
HMGN1HMGN1 isoform 11. (116 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1273 aa)
MAXMYC associated factor X. (162 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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