STRINGSTRING
ID3 ID3 ELK4 ELK4 MYOD1 MYOD1 ACVRL1 ACVRL1 MYF6 MYF6 MYF5 MYF5 ELK3 ELK3 FLT1 FLT1 RB1 RB1 TCF12 TCF12 IGF1R IGF1R TGIF1 TGIF1 SMAD4 SMAD4 IRS1 IRS1 BMP2 BMP2 RBL1 RBL1 KDR KDR NFKB1 NFKB1 EGF EGF CCNA2 CCNA2 SMAD1 SMAD1 BMP6 BMP6 TCF4 TCF4 CTNNB1 CTNNB1 PAX5 PAX5 ATF3 ATF3 RELA RELA ID1 ID1 HES1 HES1 IFI16 IFI16 IGF1 IGF1 RBL2 RBL2 ID4 ID4 SREBF1 SREBF1 CD40LG CD40LG SMAD5 SMAD5 PAX8 PAX8 CCNE1 CCNE1 SMAD3 SMAD3 PSMD4 PSMD4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ID3Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. (119 aa)
ELK4ELK4, ETS-domain protein (SRF accessory protein 1). (431 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
MYF6Myogenic factor 6. (242 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
ELK3ELK3, ETS-domain protein (SRF accessory protein 2). (407 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
RB1RB transcriptional corepressor 1. (928 aa)
TCF12Transcription factor 12. (706 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
TGIF1Homeobox protein TGIF1; Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activitie [...] (401 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
TCF4Transcription factor 4. (773 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
PAX5PAX5 isoform 1. (391 aa)
ATF3Activating transcription factor 3. (181 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (155 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
IFI16IFI16 isoform 4. (733 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PAX8PAX8 isoform 1. (456 aa)
CCNE1CCNE1 isoform 1; Belongs to the cyclin family. (411 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
PSMD4PSMD4 isoform 2. (382 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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