(29 nodes) G13 signaling pathway network (Pan troglodytes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	ROCK1	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
	MYBPH	Myosin binding protein H. (477 aa)
	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta. (201 aa)
	CFL2	Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
	CYFIP1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	PFN1	Profilin; Belongs to the profilin family. (140 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	GNA13	Guanine nucleotide binding protein (G protein), alpha 13. (377 aa)
	IQGAP2	IQ motif containing GTPase activating protein 2. (1600 aa)
	PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
	RHPN2	RHPN2 isoform 2. (686 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (968 aa)
	RTKN	RTKN isoform 2. (563 aa)
	MYL1	Myosin light chain 1. (192 aa)
	RHOA	Ras homolog family member A. (193 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
	SH3RF1	SH3 domain containing ring finger 1. (888 aa)
	WASL	WASP like actin nucleation promoting factor. (505 aa)
	ARHGDIG	Rho GDP dissociation inhibitor gamma. (226 aa)
	PAK3	Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (331 aa)
	MAPK10	Mitogen-activated protein kinase. (551 aa)
	PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha. (406 aa)
	MAP3K4	MAP3K4 isoform 5. (1601 aa)
	DIAPH1	DIAPH1 isoform 4. (1278 aa)
	CDC42	Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
	PKN1	PKN1 isoform 2. (948 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGDIB	ARHGDIG	ENSPTRP00000008071	ENSPTRP00000053824	Rho GDP dissociation inhibitor (GDI) beta.	Rho GDP dissociation inhibitor gamma.	0.917
ARHGDIB	CDC42	ENSPTRP00000008071	ENSPTRP00000077648	Rho GDP dissociation inhibitor (GDI) beta.	Cell division cycle 42 (GTP binding protein, 25kDa).	0.861
ARHGDIB	RHOA	ENSPTRP00000008071	ENSPTRP00000025759	Rho GDP dissociation inhibitor (GDI) beta.	Ras homolog family member A.	0.991
ARHGDIG	ARHGDIB	ENSPTRP00000053824	ENSPTRP00000008071	Rho GDP dissociation inhibitor gamma.	Rho GDP dissociation inhibitor (GDI) beta.	0.917
ARHGDIG	CDC42	ENSPTRP00000053824	ENSPTRP00000077648	Rho GDP dissociation inhibitor gamma.	Cell division cycle 42 (GTP binding protein, 25kDa).	0.868
ARHGDIG	RHOA	ENSPTRP00000053824	ENSPTRP00000025759	Rho GDP dissociation inhibitor gamma.	Ras homolog family member A.	0.987
ARHGEF1	CDC42	ENSPTRP00000018955	ENSPTRP00000077648	Rho guanine nucleotide exchange factor 1.	Cell division cycle 42 (GTP binding protein, 25kDa).	0.632
ARHGEF1	CFL2	ENSPTRP00000018955	ENSPTRP00000010616	Rho guanine nucleotide exchange factor 1.	Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family.	0.404
ARHGEF1	GNA13	ENSPTRP00000018955	ENSPTRP00000016220	Rho guanine nucleotide exchange factor 1.	Guanine nucleotide binding protein (G protein), alpha 13.	0.999
ARHGEF1	RHOA	ENSPTRP00000018955	ENSPTRP00000025759	Rho guanine nucleotide exchange factor 1.	Ras homolog family member A.	0.995
ARHGEF1	ROCK1	ENSPTRP00000018955	ENSPTRP00000084841	Rho guanine nucleotide exchange factor 1.	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...]	0.657
ARHGEF1	ROCK2	ENSPTRP00000018955	ENSPTRP00000063417	Rho guanine nucleotide exchange factor 1.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.656
CDC42	ARHGDIB	ENSPTRP00000077648	ENSPTRP00000008071	Cell division cycle 42 (GTP binding protein, 25kDa).	Rho GDP dissociation inhibitor (GDI) beta.	0.861
CDC42	ARHGDIG	ENSPTRP00000077648	ENSPTRP00000053824	Cell division cycle 42 (GTP binding protein, 25kDa).	Rho GDP dissociation inhibitor gamma.	0.868
CDC42	ARHGEF1	ENSPTRP00000077648	ENSPTRP00000018955	Cell division cycle 42 (GTP binding protein, 25kDa).	Rho guanine nucleotide exchange factor 1.	0.632
CDC42	CFL2	ENSPTRP00000077648	ENSPTRP00000010616	Cell division cycle 42 (GTP binding protein, 25kDa).	Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family.	0.761
CDC42	CYFIP1	ENSPTRP00000077648	ENSPTRP00000011648	Cell division cycle 42 (GTP binding protein, 25kDa).	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.721
CDC42	DIAPH1	ENSPTRP00000077648	ENSPTRP00000075718	Cell division cycle 42 (GTP binding protein, 25kDa).	DIAPH1 isoform 4.	0.689
CDC42	GNA13	ENSPTRP00000077648	ENSPTRP00000016220	Cell division cycle 42 (GTP binding protein, 25kDa).	Guanine nucleotide binding protein (G protein), alpha 13.	0.558
CDC42	IQGAP1	ENSPTRP00000077648	ENSPTRP00000012743	Cell division cycle 42 (GTP binding protein, 25kDa).	IQ motif containing GTPase activating protein 1.	0.999