STRINGSTRING
CNTN1 CNTN1 PIK3R2 PIK3R2 NOTCH3 NOTCH3 SMAD4 SMAD4 TP53 TP53 FURIN FURIN APH1B APH1B ADAM10 ADAM10 YY1 YY1 PSEN1 PSEN1 NFKBIA NFKBIA DTX1 DTX1 MAML2 MAML2 STAT3 STAT3 SMAD3 SMAD3 MEF2C MEF2C NCOR2 NCOR2 WDR12 WDR12 AKT1 AKT1 LFNG LFNG JAK2 JAK2 LEF1 LEF1 MAML3 MAML3 RBPJ RBPJ PIK3R1 PIK3R1 NOTCH2 NOTCH2 MFNG MFNG DLL4 DLL4 SKP1 SKP1 EGFR EGFR HEY1 HEY1 SNW1 SNW1 HES1 HES1 NUMBL NUMBL NOTCH4 NOTCH4 RING1 RING1 MAML1 MAML1 RELA RELA MAPK3 MAPK3 ADAM17 ADAM17 HDAC2 HDAC2 SIN3A SIN3A NUMB NUMB APH1A APH1A MAGEA1 MAGEA1 NOTCH1 NOTCH1 CCN3 CCN3 CUL1 CUL1 DLL1 DLL1 HEY2 HEY2 SKP2 SKP2 SAP30 SAP30 FBXW7 FBXW7 NCSTN NCSTN HIVEP3 HIVEP3 APP APP SMAD1 SMAD1 EGF EGF GPR156 GPR156 KAT2B KAT2B EP300 EP300 RBX1 RBX1 MAPK1 MAPK1 POFUT1 POFUT1 JAG1 JAG1 PSENEN PSENEN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNTN1CNTN1 isoform 1. (1028 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
FURINFurin (Paired basic amino acid cleaving enzyme); Belongs to the peptidase S8 family. (794 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
YY1YY1 transcription factor. (414 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (317 aa)
DTX1Deltex E3 ubiquitin ligase 1. (620 aa)
MAML2Mastermind like transcriptional coactivator 2. (1150 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
NCOR2Nuclear receptor corepressor 2. (2514 aa)
WDR12Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (433 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
LFNGLFNG isoform 5. (405 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
MAML3MAML3 isoform 1. (1134 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. (321 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
SKP1T0093123 isoform 1; Belongs to the SKP1 family. (163 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
SNW1SNW domain containing 1. (571 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
NUMBLNUMBL isoform 1. (611 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
RING1E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] (406 aa)
MAML1MAML1 isoform 1. (1016 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ADAM17ADAM17 isoform 3. (999 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
MAGEA1MAGE family member A1. (309 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
CCN3NOV isoform 1. (357 aa)
CUL1CUL1 isoform 1; Belongs to the cullin family. (776 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
SKP2S-phase kinase-associated protein 2 (P45). (425 aa)
SAP30Sin3A-associated protein, 30kDa. (220 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
NCSTNNCSTN isoform 1. (721 aa)
HIVEP3Human immunodeficiency virus type I enhancer binding protein 3. (2405 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GPR156G protein-coupled receptor 156. (814 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (832 aa)
EP300E1A binding protein p300. (2175 aa)
RBX1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
POFUT1GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...] (388 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PSENENT0105581 isoform 1. (101 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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