STRINGSTRING
MYLK2 MYLK2 ITGA10 ITGA10 CAPN9 CAPN9 VCL VCL HRAS HRAS PAK1 PAK1 ITGA5 ITGA5 ITGA7 ITGA7 MAPK6 MAPK6 MAP2K5 MAP2K5 CSK CSK ITGAM ITGAM ITGAD ITGAD MAPK7 MAPK7 ITGA3 ITGA3 GRB2 GRB2 MAP2K2 MAP2K2 PIK3R2 PIK3R2 ITGA4 ITGA4 MAPK1 MAPK1 CAV3 CAV3 CAPN7 CAPN7 ITGA9 ITGA9 RHO RHO ITGA1 ITGA1 CAV1 CAV1 ITGAV ITGAV ITGB5 ITGB5 SHC1 SHC1 SOS1 SOS1 MAP2K6 MAP2K6 PAK3 PAK3 MAP2K1 MAP2K1 ROCK2 ROCK2 SHC3 SHC3 ILK ILK CAPN1 CAPN1 ITGB3 ITGB3 RAC2 RAC2 ITGB1 ITGB1 MAPK10 MAPK10 RAP1B RAP1B ITGB7 ITGB7 PXN-2 PXN-2 GIT2 GIT2 SRC SRC FYN FYN CDC42 CDC42 ITGAX ITGAX BRAF BRAF BCAR1 BCAR1 CAPN11 CAPN11 ITGB4 ITGB4 ITGA2 ITGA2 ITGB8 ITGB8 AKT1 AKT1 CRK CRK ITGA11 ITGA11 RAP1A RAP1A ROCK1 ROCK1 ITGA8 ITGA8 ITGA6 ITGA6 AKT2 AKT2 VAV3 VAV3 ITGB2 ITGB2 CAPN6 CAPN6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYLK2MYLK2 isoform 1. (596 aa)
ITGA10ITGA10 isoform 1; Belongs to the integrin alpha chain family. (1167 aa)
CAPN9CAPN9 isoform 1; Belongs to the peptidase C2 family. (690 aa)
VCLVCL isoform 2. (1134 aa)
HRASV-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
ITGA5ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
ITGA7ITGA7 isoform 6; Belongs to the integrin alpha chain family. (1181 aa)
MAPK6Mitogen-activated protein kinase 6. (721 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
CSKTyrosine-protein kinase. (450 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1152 aa)
ITGADITGAD isoform 1; Belongs to the integrin alpha chain family. (1161 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
ITGA3ITGA3 isoform 6; Belongs to the integrin alpha chain family. (1066 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
ITGA4Integrin, alpha 4 (Antigen CD49D, alpha 4 subunit of VLA-4 receptor); Belongs to the integrin alpha chain family. (1032 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CAPN7CAPN7 isoform 3; Belongs to the peptidase C2 family. (813 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
RHORhodopsin. (348 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
PAK3Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
SHC3SHC3 isoform 2. (598 aa)
ILKIntegrin-linked kinase. (533 aa)
CAPN1Calpain 1, (Mu/I) large subunit; Belongs to the peptidase C2 family. (733 aa)
ITGB3Integrin beta-3 isoform X2. (837 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2). (207 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MAPK10Mitogen-activated protein kinase. (551 aa)
RAP1BRas-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (802 aa)
PXN-2PXN isoform 9. (1081 aa)
GIT2G protein-coupled receptor kinase interacting ArfGAP 2. (760 aa)
SRCTyrosine-protein kinase. (542 aa)
FYNTyrosine-protein kinase. (537 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1169 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
CAPN11CAPN11 isoform 2; Belongs to the peptidase C2 family. (739 aa)
ITGB4Integrin beta. (1822 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1206 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1368 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
VAV3VAV3 isoform 2. (927 aa)
ITGB2Integrin beta. (863 aa)
CAPN6CAPN6 isoform 1; Belongs to the peptidase C2 family. (651 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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