(39 nodes) Glycine, serine and threonine metabolism network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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protein homology

Your Input:
	CTH	Cystathionase (Cystathionine gamma-lyase). (405 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (573 aa)
	PGAM1	Probable phosphoglycerate mutase 4. (254 aa)
	SDS	Serine dehydratase. (328 aa)
	SDSL	Serine dehydratase-like. (329 aa)
	GATM	Glycine amidinotransferase. (423 aa)
	GCSH	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (173 aa)
	SRR	Serine racemase. (340 aa)
	PIPOX	PIPOX isoform 6. (390 aa)
	CBS	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
	AMT	Aminomethyltransferase, mitochondrial isoform X2. (403 aa)
	ALAS1	5-aminolevulinate synthase. (640 aa)
	CHDH	Choline dehydrogenase. (594 aa)
	AGXT2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (514 aa)
	DMGDH	Dimethylglycine dehydrogenase. (866 aa)
	BHMT	BHMT isoform 1; Involved in the regulation of homocysteine metabolism. (470 aa)
	GNMT	Glycine N-methyltransferase. (295 aa)
	PSPH	Phosphoserine phosphatase. (225 aa)
	BPGM	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (259 aa)
	PSAT1	Phosphoserine aminotransferase. (370 aa)
	SARDH	Sarcosine dehydrogenase. (918 aa)
	MAOA	Amine oxidase. (527 aa)
	MAOB	Amine oxidase. (520 aa)
	GLYCTK	GLYCTK isoform 1. (523 aa)
	GLDC	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1020 aa)
	GCAT	Glycine C-acetyltransferase. (445 aa)
	AOC3	Amine oxidase. (763 aa)
	GAMT	Guanidinoacetate N-methyltransferase. (269 aa)
	LOC107969159	Membrane primary amine oxidase-like. (753 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
	ALDH7A1	ALDH7A1 isoform 8; Belongs to the aldehyde dehydrogenase family. (556 aa)
	PGAM2-2	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
	LOC465383-2	Uncharacterized protein. (72 aa)
	AOC2-2	Amine oxidase. (756 aa)
	GRHPR	Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (358 aa)
	ALAS2	5-aminolevulinate synthase. (587 aa)
	LOC463989	L-threonine 3-dehydrogenase, mitochondrial. (369 aa)
	DAO	D-amino acid oxidase. (347 aa)
	DLD	Dihydrolipoyl dehydrogenase. (538 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGXT2	ALAS1	ENSPTRP00000028785	ENSPTRP00000025879	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	5-aminolevulinate synthase.	0.910
AGXT2	ALAS2	ENSPTRP00000028785	ENSPTRP00000076950	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	5-aminolevulinate synthase.	0.910
AGXT2	ALDH7A1	ENSPTRP00000028785	ENSPTRP00000064794	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	ALDH7A1 isoform 8; Belongs to the aldehyde dehydrogenase family.	0.943
AGXT2	CTH	ENSPTRP00000028785	ENSPTRP00000001478	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Cystathionase (Cystathionine gamma-lyase).	0.931
AGXT2	DAO	ENSPTRP00000028785	ENSPTRP00000084772	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	D-amino acid oxidase.	0.940
AGXT2	GATM	ENSPTRP00000028785	ENSPTRP00000012025	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glycine amidinotransferase.	0.928
AGXT2	GCAT	ENSPTRP00000028785	ENSPTRP00000049680	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glycine C-acetyltransferase.	0.918
AGXT2	GLDC	ENSPTRP00000028785	ENSPTRP00000049477	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.963
AGXT2	GNMT	ENSPTRP00000028785	ENSPTRP00000031060	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glycine N-methyltransferase.	0.917
AGXT2	GRHPR	ENSPTRP00000028785	ENSPTRP00000075075	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.869
AGXT2	PIPOX	ENSPTRP00000028785	ENSPTRP00000015268	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	PIPOX isoform 6.	0.945
AGXT2	SARDH	ENSPTRP00000028785	ENSPTRP00000036833	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Sarcosine dehydrogenase.	0.931
AGXT2	SDS	ENSPTRP00000028785	ENSPTRP00000009317	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Serine dehydratase.	0.859
AGXT2	SDSL	ENSPTRP00000028785	ENSPTRP00000009319	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Serine dehydratase-like.	0.859
AGXT2	SHMT2	ENSPTRP00000028785	ENSPTRP00000063004	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.919
ALAS1	AGXT2	ENSPTRP00000025879	ENSPTRP00000028785	5-aminolevulinate synthase.	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.910
ALAS1	ALAS2	ENSPTRP00000025879	ENSPTRP00000076950	5-aminolevulinate synthase.	5-aminolevulinate synthase.	0.953
ALAS1	DAO	ENSPTRP00000025879	ENSPTRP00000084772	5-aminolevulinate synthase.	D-amino acid oxidase.	0.918
ALAS1	GATM	ENSPTRP00000025879	ENSPTRP00000012025	5-aminolevulinate synthase.	Glycine amidinotransferase.	0.900
ALAS1	GCAT	ENSPTRP00000025879	ENSPTRP00000049680	5-aminolevulinate synthase.	Glycine C-acetyltransferase.	0.910