(32 nodes) Tyrosine metabolism network (Pan troglodytes)

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	GOT1	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa)
	TYR	TYR isoform 1. (529 aa)
	HPD	4-hydroxyphenylpyruvate dioxygenase. (393 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	TAT	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
	PNMT	Phenylethanolamine N-methyltransferase. (282 aa)
	COMT	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (271 aa)
	HGD	Homogentisate 1,2-dioxygenase. (445 aa)
	ADH5	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (383 aa)
	ADH6	Alcohol dehydrogenase 6 (class V). (375 aa)
	ADH1A	Alcohol dehydrogenase 1A (class I), alpha polypeptide. (375 aa)
	DBH	Dopamine beta-hydroxylase. (617 aa)
	MAOA	Amine oxidase. (527 aa)
	MAOB	Amine oxidase. (520 aa)
	AOX1	Aldehyde oxidase 1. (1338 aa)
	ALDH3A1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (453 aa)
	AOC3	Amine oxidase. (763 aa)
	IL4I1	Amine oxidase. (589 aa)
	LOC107969159	Membrane primary amine oxidase-like. (753 aa)
	ADH7	ADH7 isoform 5. (394 aa)
	ALDH3B1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (468 aa)
	ADH4	Alcohol dehydrogenase 4 (class II), pi polypeptide. (399 aa)
	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. (375 aa)
	TYRP1	TYRP1 isoform 6. (578 aa)
	AOC2-2	Amine oxidase. (756 aa)
	GSTZ1	Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (217 aa)
	FAHD1	FAHD1 isoform 2. (248 aa)
	ALDH3B2	Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family. (487 aa)
	MIF	Macrophage migration inhibitory factor. (115 aa)
	DDC	Dopa decarboxylase. (489 aa)
	FAH	Fumarylacetoacetase. (427 aa)
	GOT1L1	GOT1L1 isoform 1. (415 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH1A	ADH1B	ENSPTRP00000028008	ENSPTRP00000071388	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.	0.973
ADH1A	ADH6	ENSPTRP00000028008	ENSPTRP00000028007	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Alcohol dehydrogenase 6 (class V).	0.450
ADH1A	ALDH3A1	ENSPTRP00000028008	ENSPTRP00000052956	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.944
ADH1A	ALDH3B1	ENSPTRP00000028008	ENSPTRP00000064442	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.937
ADH1A	ALDH3B2	ENSPTRP00000028008	ENSPTRP00000083329	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family.	0.937
ADH1A	AOX1	ENSPTRP00000028008	ENSPTRP00000048899	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Aldehyde oxidase 1.	0.917
ADH1A	COMT	ENSPTRP00000028008	ENSPTRP00000024231	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	0.904
ADH1A	MAOA	ENSPTRP00000028008	ENSPTRP00000037440	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Amine oxidase.	0.918
ADH1A	MAOB	ENSPTRP00000028008	ENSPTRP00000037441	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Amine oxidase.	0.920
ADH1B	ADH1A	ENSPTRP00000071388	ENSPTRP00000028008	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	0.973
ADH1B	ADH6	ENSPTRP00000071388	ENSPTRP00000028007	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.	Alcohol dehydrogenase 6 (class V).	0.466
ADH1B	ALDH3A1	ENSPTRP00000071388	ENSPTRP00000052956	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.948
ADH1B	ALDH3B1	ENSPTRP00000071388	ENSPTRP00000064442	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.937
ADH1B	ALDH3B2	ENSPTRP00000071388	ENSPTRP00000083329	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.	Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family.	0.937
ADH1B	AOX1	ENSPTRP00000071388	ENSPTRP00000048899	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.	Aldehyde oxidase 1.	0.922
ADH1B	COMT	ENSPTRP00000071388	ENSPTRP00000024231	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	0.923
ADH1B	MAOA	ENSPTRP00000071388	ENSPTRP00000037440	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.	Amine oxidase.	0.928
ADH1B	MAOB	ENSPTRP00000071388	ENSPTRP00000037441	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.	Amine oxidase.	0.923
ADH4	ADH6	ENSPTRP00000069873	ENSPTRP00000028007	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Alcohol dehydrogenase 6 (class V).	0.511
ADH4	ALDH3A1	ENSPTRP00000069873	ENSPTRP00000052956	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.976