(17 nodes) Glycosaminoglycan degradation network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HPSE2	Heparanase 2 (inactive). (592 aa)
	GALNS	Galactosamine (N-acetyl)-6-sulfate sulfatase. (502 aa)
	NAGLU	N-acetyl-alpha-glucosaminidase. (743 aa)
	HYAL3	Hyaluronidase-3 precursor. (417 aa)
	IDUA	IDUA isoform 1. (653 aa)
	HYAL2	Hyaluronidase. (473 aa)
	HYAL4	Hyaluronidase. (476 aa)
	GNS	GNS isoform 3. (584 aa)
	ARSB	Arylsulfatase B. (535 aa)
	HGSNAT	Heparan-alpha-glucosaminide N-acetyltransferase. (692 aa)
	SPAM1	Hyaluronidase. (511 aa)
	GLB1	Beta-galactosidase. (699 aa)
	SGSH	N-sulfoglucosamine sulfohydrolase. (502 aa)
	IDS	T0188098 isoform 1. (550 aa)
	HEXB	Beta-hexosaminidase. (557 aa)
	GUSB-2	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (651 aa)
	CELF6-2	CUGBP Elav-like family member 6 isoform X1. (538 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSB	GNS	ENSPTRP00000067780	ENSPTRP00000066176	Arylsulfatase B.	GNS isoform 3.	0.430
ARSB	GUSB-2	ENSPTRP00000067780	ENSPTRP00000089661	Arylsulfatase B.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.536
ARSB	HYAL2	ENSPTRP00000067780	ENSPTRP00000047133	Arylsulfatase B.	Hyaluronidase.	0.912
ARSB	HYAL3	ENSPTRP00000067780	ENSPTRP00000025808	Arylsulfatase B.	Hyaluronidase-3 precursor.	0.906
ARSB	HYAL4	ENSPTRP00000067780	ENSPTRP00000047656	Arylsulfatase B.	Hyaluronidase.	0.906
ARSB	IDUA	ENSPTRP00000067780	ENSPTRP00000027243	Arylsulfatase B.	IDUA isoform 1.	0.955
ARSB	NAGLU	ENSPTRP00000067780	ENSPTRP00000015676	Arylsulfatase B.	N-acetyl-alpha-glucosaminidase.	0.435
ARSB	SPAM1	ENSPTRP00000067780	ENSPTRP00000074848	Arylsulfatase B.	Hyaluronidase.	0.912
CELF6-2	GLB1	ENSPTRP00000089716	ENSPTRP00000083644	CUGBP Elav-like family member 6 isoform X1.	Beta-galactosidase.	0.943
CELF6-2	GNS	ENSPTRP00000089716	ENSPTRP00000066176	CUGBP Elav-like family member 6 isoform X1.	GNS isoform 3.	0.920
CELF6-2	HEXB	ENSPTRP00000089716	ENSPTRP00000087394	CUGBP Elav-like family member 6 isoform X1.	Beta-hexosaminidase.	0.999
GALNS	GLB1	ENSPTRP00000014434	ENSPTRP00000083644	Galactosamine (N-acetyl)-6-sulfate sulfatase.	Beta-galactosidase.	0.980
GALNS	GNS	ENSPTRP00000014434	ENSPTRP00000066176	Galactosamine (N-acetyl)-6-sulfate sulfatase.	GNS isoform 3.	0.451
GALNS	GUSB-2	ENSPTRP00000014434	ENSPTRP00000089661	Galactosamine (N-acetyl)-6-sulfate sulfatase.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.465
GALNS	HGSNAT	ENSPTRP00000014434	ENSPTRP00000073539	Galactosamine (N-acetyl)-6-sulfate sulfatase.	Heparan-alpha-glucosaminide N-acetyltransferase.	0.475
GALNS	IDUA	ENSPTRP00000014434	ENSPTRP00000027243	Galactosamine (N-acetyl)-6-sulfate sulfatase.	IDUA isoform 1.	0.589
GALNS	NAGLU	ENSPTRP00000014434	ENSPTRP00000015676	Galactosamine (N-acetyl)-6-sulfate sulfatase.	N-acetyl-alpha-glucosaminidase.	0.579
GLB1	CELF6-2	ENSPTRP00000083644	ENSPTRP00000089716	Beta-galactosidase.	CUGBP Elav-like family member 6 isoform X1.	0.943
GLB1	GALNS	ENSPTRP00000083644	ENSPTRP00000014434	Beta-galactosidase.	Galactosamine (N-acetyl)-6-sulfate sulfatase.	0.980
GLB1	GNS	ENSPTRP00000083644	ENSPTRP00000066176	Beta-galactosidase.	GNS isoform 3.	0.937