STRINGSTRING
DEGS1 DEGS1 SGMS1 SGMS1 SMPD1 SMPD1 ACER3 ACER3 SPTLC2 SPTLC2 GALC GALC DEGS2 DEGS2 SMPD3 SMPD3 ENPP7 ENPP7 KDSR KDSR PLPP2 PLPP2 ACER1 ACER1 CERS4 CERS4 SPHK2 SPHK2 NEU2 NEU2 GAL3ST1 GAL3ST1 ARSA ARSA UGT8 UGT8 PLPP1 PLPP1 SMPD2 SMPD2 GBA2 GBA2 GLA GLA CERS2 CERS2 GBA GBA SPHK1 SPHK1 PSAPL1 PSAPL1 SPTLC3 SPTLC3 CERS3 CERS3 CERS1 CERS1 ASAH1 ASAH1 PSAP PSAP UGCG UGCG SGMS2 SGMS2 CERS6 CERS6 NEU1 NEU1 SGPL1 SGPL1 SGPP2 SGPP2 PLPP3 PLPP3 LOC459619 LOC459619 GLB1 GLB1 NEU4 NEU4 ASAH2 ASAH2 NEU3 NEU3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DEGS1Degenerative spermatocyte homolog 1, lipid desaturase. (323 aa)
SGMS1Sphingomyelin synthase 1. (419 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (504 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
SPTLC2Serine palmitoyltransferase, long chain base subunit 2. (564 aa)
GALCGalactosylceramidase. (685 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (323 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (458 aa)
KDSR3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
PLPP2PLPP2 isoform 5. (309 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
CERS4CERS4 isoform 1. (394 aa)
SPHK2Sphingosine kinase 2. (255 aa)
NEU2Neuraminidase 2. (380 aa)
GAL3ST1Galactosylceramide sulfotransferase. (423 aa)
ARSAArylsulfatase A. (509 aa)
UGT8UGT8 isoform 1; Belongs to the UDP-glycosyltransferase family. (541 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
SMPD2Sphingomyelin phosphodiesterase 2, neutral membrane (Neutral sphingomyelinase). (423 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (927 aa)
GLAAlpha-galactosidase. (429 aa)
CERS2LAG1 homolog, ceramide synthase 2. (380 aa)
GBALysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (536 aa)
SPHK1Sphingosine kinase 1. (470 aa)
PSAPL1Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. (521 aa)
SPTLC3Serine palmitoyltransferase, long chain base subunit 3. (552 aa)
CERS3CERS3 isoform 1. (383 aa)
CERS1Ceramide synthase 1. (239 aa)
ASAH1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] (411 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (524 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (394 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
CERS6Ceramide synthase 6. (392 aa)
NEU1Sialidase 1 (Lysosomal sialidase). (417 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (399 aa)
PLPP3T0036865 isoform 1. (342 aa)
LOC459619Uncharacterized protein. (867 aa)
GLB1Beta-galactosidase. (699 aa)
NEU4NEU4 isoform 10. (497 aa)
ASAH2Neutral ceramidase. (780 aa)
NEU3NEU3 isoform 1. (461 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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