(38 nodes) Pyruvate metabolism network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ALDH9A1	Aldehyde dehydrogenase 9 family, member A1; Belongs to the aldehyde dehydrogenase family. (518 aa)
	FH	Fumarate hydratase. (510 aa)
	LDHAL6A	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
	ME3	Malic enzyme. (604 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
	LDHB	L-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. (334 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
	LDHAL6B	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
	LDHD	Lactate dehydrogenase D. (484 aa)
	ACSS1	Acetyl-coenzyme A synthetase. (688 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	PDHB	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
	PDHA2	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (441 aa)
	ACOT12	Acyl-CoA thioesterase 12. (555 aa)
	GLO1	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
	ME1	Malic enzyme. (572 aa)
	ACAT2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	MDH2	Malate dehydrogenase. (338 aa)
	ALDH1B1	Aldehyde dehydrogenase 1 family, member B1; Belongs to the aldehyde dehydrogenase family. (517 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1179 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
	ACYP2	Acylphosphatase. (172 aa)
	LOC104002294	LOW QUALITY PROTEIN: pyruvate kinase PKM-like. (501 aa)
	ALDH7A1	ALDH7A1 isoform 8; Belongs to the aldehyde dehydrogenase family. (556 aa)
	LOC464999	LOW QUALITY PROTEIN: L-lactate dehydrogenase A chain-like. (332 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2383 aa)
	GRHPR	Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (358 aa)
	ACYP1	Acylphosphatase. (129 aa)
	ACACB	ACACB isoform 2. (2458 aa)
	ACSS2	Acyl-CoA synthetase short chain family member 2. (714 aa)
	LDHA	L-lactate dehydrogenase A chain. (361 aa)
	ALDH3A2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (508 aa)
	DLD	Dihydrolipoyl dehydrogenase. (538 aa)
	MDH1	Malate dehydrogenase. (352 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
	ALDH2	T0055793 isoform 1. (517 aa)
	ME2	Malic enzyme. (581 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSPTRP00000074254	ENSPTRP00000079596	Acetyl-CoA carboxylase alpha.	ACACB isoform 2.	0.934
ACACA	ACAT1	ENSPTRP00000074254	ENSPTRP00000007309	Acetyl-CoA carboxylase alpha.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.964
ACACA	ACAT2	ENSPTRP00000074254	ENSPTRP00000032016	Acetyl-CoA carboxylase alpha.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.943
ACACA	ACOT12	ENSPTRP00000074254	ENSPTRP00000029185	Acetyl-CoA carboxylase alpha.	Acyl-CoA thioesterase 12.	0.904
ACACA	ACSS1	ENSPTRP00000074254	ENSPTRP00000022860	Acetyl-CoA carboxylase alpha.	Acetyl-coenzyme A synthetase.	0.936
ACACA	ACSS2	ENSPTRP00000074254	ENSPTRP00000080199	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase short chain family member 2.	0.950
ACACA	DLAT	ENSPTRP00000074254	ENSPTRP00000007349	Acetyl-CoA carboxylase alpha.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.921
ACACA	MDH1	ENSPTRP00000074254	ENSPTRP00000088176	Acetyl-CoA carboxylase alpha.	Malate dehydrogenase.	0.569
ACACA	ME1	ENSPTRP00000074254	ENSPTRP00000031411	Acetyl-CoA carboxylase alpha.	Malic enzyme.	0.506
ACACA	ME3	ENSPTRP00000074254	ENSPTRP00000007130	Acetyl-CoA carboxylase alpha.	Malic enzyme.	0.425
ACACA	PC	ENSPTRP00000074254	ENSPTRP00000045149	Acetyl-CoA carboxylase alpha.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.627
ACACA	PCK1	ENSPTRP00000074254	ENSPTRP00000023500	Acetyl-CoA carboxylase alpha.	Phosphoenolpyruvate carboxykinase 1.	0.463
ACACA	PCK2	ENSPTRP00000074254	ENSPTRP00000010507	Acetyl-CoA carboxylase alpha.	Phosphoenolpyruvate carboxykinase 2, mitochondrial.	0.507
ACACA	PKLR	ENSPTRP00000074254	ENSPTRP00000056053	Acetyl-CoA carboxylase alpha.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.509
ACACB	ACACA	ENSPTRP00000079596	ENSPTRP00000074254	ACACB isoform 2.	Acetyl-CoA carboxylase alpha.	0.934
ACACB	ACAT1	ENSPTRP00000079596	ENSPTRP00000007309	ACACB isoform 2.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.942
ACACB	ACAT2	ENSPTRP00000079596	ENSPTRP00000032016	ACACB isoform 2.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.942
ACACB	ACOT12	ENSPTRP00000079596	ENSPTRP00000029185	ACACB isoform 2.	Acyl-CoA thioesterase 12.	0.903
ACACB	ACSS1	ENSPTRP00000079596	ENSPTRP00000022860	ACACB isoform 2.	Acetyl-coenzyme A synthetase.	0.927
ACACB	ACSS2	ENSPTRP00000079596	ENSPTRP00000080199	ACACB isoform 2.	Acyl-CoA synthetase short chain family member 2.	0.933