(55 nodes) Metabolism of xenobiotics by cytochrome P450 network (Pan troglodytes)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	AKR7A2	Aldo-keto reductase family 7, member A2 (Aflatoxin aldehyde reductase). (359 aa)
	GSTM1	GSTM1 isoform 3; Belongs to the GST superfamily. (218 aa)
	GSTM5	Glutathione S-transferase. (217 aa)
	MGST3	Microsomal glutathione S-transferase 3. (165 aa)
	HSD11B1	Hydroxysteroid (11-beta) dehydrogenase 1. (292 aa)
	EPHX1	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (455 aa)
	CYP2C9	Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. (490 aa)
	CYP2E1	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (531 aa)
	HSD11B1L	Hydroxysteroid 11-beta dehydrogenase 1 like. (334 aa)
	SULT2A1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
	CYP1B1	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
	CBR1	Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
	CBR3	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
	LOC470264	Glutathione S-transferase theta 1; Belongs to the GST superfamily. (240 aa)
	UGT2B4	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	HPGDS	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
	ADH5	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (383 aa)
	ADH6	Alcohol dehydrogenase 6 (class V). (375 aa)
	ADH1A	Alcohol dehydrogenase 1A (class I), alpha polypeptide. (375 aa)
	MGST2	Microsomal glutathione S-transferase 2. (147 aa)
	GSTA1	Glutathione S-transferase. (222 aa)
	GSTA4	Glutathione S-transferase alpha 4. (222 aa)
	CYP3A5	CYP3A5 isoform 1. (493 aa)
	CYP2B6	Cytochrome P450 family 2 subfamily B member 6; Belongs to the cytochrome P450 family. (491 aa)
	CYP2D6	Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] (488 aa)
	GSTP1	Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
	LOC101058187	CYP2A13 isoform 1; Belongs to the cytochrome P450 family. (329 aa)
	GSTA2	Glutathione S-transferase alpha 2. (222 aa)
	ALDH3A1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (453 aa)
	UGT2A3	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
	CYP1A1	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
	GSTM4	Glutathione S-transferase mu 4; Belongs to the GST superfamily. (218 aa)
	GSTO1	Glutathione S-transferase omega 1. (241 aa)
	UGT2B7	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
	ADH7	ADH7 isoform 5. (394 aa)
	ALDH3B1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (468 aa)
	GSTA5	Glutathione S-transferase alpha 5; Belongs to the GST superfamily. (222 aa)
	LOC472094	Glutathione S-transferase Mu 2-like. (196 aa)
	GSTM3-2	Glutathione S-transferase. (225 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (504 aa)
	MGST1	Microsomal glutathione S-transferase 1. (155 aa)
	ADH4	Alcohol dehydrogenase 4 (class II), pi polypeptide. (399 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (517 aa)
	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. (375 aa)
	CYP2F1	Cytochrome P450 family 2 subfamily F. (491 aa)
	AKR7A3	Aldo-keto reductase family 7 member A3. (354 aa)
	UGT2B10	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	GSTA3	Glutathione S-transferase alpha 3; Belongs to the GST superfamily. (192 aa)
	CYP3A4	Cytochrome P450 family 3 subfamily A member 4. (507 aa)
	UGT1A3	UDP-glucuronosyltransferase 1-3 isoform X2. (534 aa)
	ALDH3B2	Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family. (487 aa)
	DHDH	Dihydrodiol dehydrogenase. (334 aa)
	GSTO2	Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
	GSTK1-2	Glutathione S-transferase kappa 1. (282 aa)
	LOC471219	UDP-glucuronosyltransferase 2B10 isoform X1. (529 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH1A	ADH1B	ENSPTRP00000028008	ENSPTRP00000071388	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.	0.973
ADH1A	ADH6	ENSPTRP00000028008	ENSPTRP00000028007	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Alcohol dehydrogenase 6 (class V).	0.450
ADH1A	ALDH3A1	ENSPTRP00000028008	ENSPTRP00000052956	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.944
ADH1A	ALDH3B1	ENSPTRP00000028008	ENSPTRP00000064442	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.937
ADH1A	ALDH3B2	ENSPTRP00000028008	ENSPTRP00000083329	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Aldehyde dehydrogenase 3 family member B2; Belongs to the aldehyde dehydrogenase family.	0.937
ADH1A	CYP2E1	ENSPTRP00000028008	ENSPTRP00000005465	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	0.949
ADH1A	GSTA1	ENSPTRP00000028008	ENSPTRP00000031234	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase.	0.692
ADH1A	GSTA2	ENSPTRP00000028008	ENSPTRP00000049984	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase alpha 2.	0.691
ADH1A	GSTA3	ENSPTRP00000028008	ENSPTRP00000075199	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase alpha 3; Belongs to the GST superfamily.	0.665
ADH1A	GSTA4	ENSPTRP00000028008	ENSPTRP00000031239	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase alpha 4.	0.678
ADH1A	GSTA5	ENSPTRP00000028008	ENSPTRP00000065433	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase alpha 5; Belongs to the GST superfamily.	0.673
ADH1A	GSTK1-2	ENSPTRP00000028008	ENSPTRP00000092731	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase kappa 1.	0.684
ADH1A	GSTM1	ENSPTRP00000028008	ENSPTRP00000001835	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	GSTM1 isoform 3; Belongs to the GST superfamily.	0.693
ADH1A	GSTM3-2	ENSPTRP00000028008	ENSPTRP00000067283	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase.	0.664
ADH1A	GSTM4	ENSPTRP00000028008	ENSPTRP00000058783	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase mu 4; Belongs to the GST superfamily.	0.664
ADH1A	GSTM5	ENSPTRP00000028008	ENSPTRP00000001837	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase.	0.664
ADH1A	GSTO1	ENSPTRP00000028008	ENSPTRP00000062706	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase omega 1.	0.669
ADH1A	GSTO2	ENSPTRP00000028008	ENSPTRP00000086076	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase omega 2; Belongs to the GST superfamily.	0.669
ADH1A	GSTP1	ENSPTRP00000028008	ENSPTRP00000047877	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Glutathione S-transferase pi 1; Belongs to the GST superfamily.	0.792
ADH1A	HPGDS	ENSPTRP00000028008	ENSPTRP00000027981	Alcohol dehydrogenase 1A (class I), alpha polypeptide.	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	0.787