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ENO1 ENO1 MTHFR MTHFR SDHB SDHB PHGDH PHGDH FH FH PFKP PFKP HKDC1 HKDC1 HK1 HK1 GLUD1 GLUD1 PGAM1 PGAM1 GOT1 GOT1 TALDO1 TALDO1 CAT CAT ME3 ME3 ACAT1 ACAT1 DLAT DLAT GAPDH GAPDH CS CS SDS SDS SDSL SDSL ACADS ACADS ESD ESD SUCLA2 SUCLA2 PCCA PCCA ALDH6A1 ALDH6A1 ADPGK ADPGK GPT2 GPT2 GOT2 GOT2 GCSH GCSH ENO3 ENO3 ALDOC ALDOC PGLS PGLS HADHA HADHA HK2 HK2 SUCLG1 SUCLG1 RPIA RPIA HIBCH HIBCH HAO1 HAO1 ACSS1 ACSS1 ACO2 ACO2 AMT AMT PDHB PDHB EHHADH EHHADH PDHA2 PDHA2 ADH5 ADH5 TKTL2 TKTL2 HK3 HK3 MMUT MMUT PGK1 PGK1 ME1 ME1 ACAT2 ACAT2 OGDH OGDH PSPH PSPH MDH2 MDH2 ACO1 ACO1 PSAT1 PSAT1 FBP2 FBP2 FBP1 FBP1 RGN RGN PRPS1 PRPS1 GPT GPT PFKL PFKL GLYCTK GLYCTK GCK GCK PC PC HAO2 HAO2 SDHA SDHA GLDC GLDC PFKM PFKM PKLR PKLR IDH3G IDH3G TPI1 TPI1 PGD PGD PGP PGP SHMT2 SHMT2 LOC104002294 LOC104002294 ALDOA ALDOA ENO2 ENO2 PGAM2-2 PGAM2-2 OGDHL OGDHL IDH3A IDH3A ACOX1 ACOX1 LOC465383-2 LOC465383-2 H6PD H6PD ALDOB ALDOB SUCLG2 SUCLG2 ACSS2 ACSS2 ENO4 ENO4 TKT TKT IDH3B IDH3B IDH2 IDH2 IDH1 IDH1 TKTL1 TKTL1 RPE RPE DLD DLD CPS1 CPS1 LOC455744 LOC455744 SDHC SDHC MDH1 MDH1 SDHD SDHD GPI GPI PKM PKM TKFC TKFC ME2 ME2 GOT1L1 GOT1L1 PRPS2 PRPS2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ENO1ENO1 isoform 2. (434 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (656 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (573 aa)
FHFumarate hydratase. (510 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (862 aa)
HKDC1HKDC1 isoform 1. (917 aa)
HK1HK1 isoform 3. (921 aa)
GLUD1Glutamate dehydrogenase 2, mitochondrial; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (558 aa)
PGAM1Probable phosphoglycerate mutase 4. (254 aa)
GOT1Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
ME3Malic enzyme. (604 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
CSCitrate synthase, mitochondrial isoform X1. (466 aa)
SDSSerine dehydratase. (328 aa)
SDSLSerine dehydratase-like. (329 aa)
ACADSAcyl-CoA dehydrogenase, C-2 to C-3 short chain. (412 aa)
ESDS-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa)
PCCAPropionyl CoA carboxylase, alpha polypeptide. (728 aa)
ALDH6A1Aldehyde dehydrogenase 6 family, member A1. (535 aa)
ADPGKADP-dependent glucokinase. (497 aa)
GPT2Glutamic pyruvate transaminase (Alanine aminotransferase) 2. (523 aa)
GOT2Aspartate aminotransferase. (430 aa)
GCSHGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (173 aa)
ENO3Enolase 3 (Beta, muscle). (434 aa)
ALDOCFructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
PGLS6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (258 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
HK2HK2 isoform 1. (917 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa)
RPIARibose 5-phosphate isomerase A. (311 aa)
HIBCH3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
HAO1Hydroxyacid oxidase 1. (370 aa)
ACSS1Acetyl-coenzyme A synthetase. (688 aa)
ACO2ACO2 isoform 2. (800 aa)
AMTAminomethyltransferase, mitochondrial isoform X2. (403 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (441 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (383 aa)
TKTL2TKTL2 isoform 1. (722 aa)
HK3HK3 isoform 2. (923 aa)
MMUTMethylmalonyl CoA mutase. (750 aa)
PGK1Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (459 aa)
ME1Malic enzyme. (572 aa)
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
PSPHPhosphoserine phosphatase. (225 aa)
MDH2Malate dehydrogenase. (338 aa)
ACO1Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. (889 aa)
PSAT1Phosphoserine aminotransferase. (370 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
RGNRegucalcin (Senescence marker protein-30). (299 aa)
PRPS1Phosphoribosyl pyrophosphate synthetase 1. (318 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
GLYCTKGLYCTK isoform 1. (523 aa)
GCKPhosphotransferase. (466 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1179 aa)
HAO2HAO2 isoform 3. (364 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (664 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1020 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (393 aa)
TPI1Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (286 aa)
PGD6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
PGPPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (321 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
LOC104002294LOW QUALITY PROTEIN: pyruvate kinase PKM-like. (501 aa)
ALDOAFructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. (729 aa)
ENO2Enolase 2 (Gamma, neuronal). (434 aa)
PGAM2-2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
OGDHLOGDHL isoform 1. (1018 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (373 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
LOC465383-2Uncharacterized protein. (72 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (802 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
SUCLG2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (440 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (714 aa)
ENO4ENO4 isoform 3. (629 aa)
TKTTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (631 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (408 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (424 aa)
TKTL1TKTL1 isoform 3. (598 aa)
RPERibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (252 aa)
DLDDihydrolipoyl dehydrogenase. (538 aa)
CPS1Carbamoyl-phosphate synthase 1, mitochondrial. (1507 aa)
LOC455744LOW QUALITY PROTEIN: phosphoglycerate kinase 1-like. (408 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
MDH1Malate dehydrogenase. (352 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (597 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
TKFCDihydroxyacetone kinase 2 homolog. (576 aa)
ME2Malic enzyme. (581 aa)
GOT1L1GOT1L1 isoform 1. (415 aa)
PRPS2Phosphoribosyl pyrophosphate synthetase 2. (321 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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